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Table 2 Classification of hepatobiliary disorders according to clinical and imaging classifications

From: Liver imaging and pregnancy: what to expect when your patient is expecting

Condition

Trimester

Symptoms

Imaging Findings

Main Role of Imaging

Imaging technique

ICP

II-III

Pruritus, increased serum bile acids, jaundice uncommon

Gallstones (without intrahepatic biliary dilatation) and/or intrahepatic lithiasis

Differential diagnosis; detection of gallstones and complications

US +++ MRCP ++

AFLP

II - III

Recent nausea and/or vomiting, polydipsia, jaundice, abdominal pain

Fatty changes, ascites

Diagnosis, assessment of complications

US ++ CT + (+++ if complications) MRI +++

Pre-eclampsia/ Eclampsia

II-III

Arterial hypertension, edema

Portal vein thrombosis, hemorrhage

Assess liver involvement as soon as possible

US ++ CT ++

HELLP Syndrome

III/post-partum

Frequent arterial hypertension, right upper quadrant pain, fever (associated with liver infarct), edema, hypovolemic shock

Infarct, hemorrhage, subcapsular hematoma, liver rupture

Diagnosis and assess complications as soon as possible

US ++ (bedside patient)

CT +++ (if unstable)

Budd-Chiari Syndrome

II - III

Abdominal pain, ascites, hepatomegaly, liver failure

Hepatic venous occlusion, regenerative nodules, hepatomegaly, portal hypertension

Detect venous thrombosis, surveillance

US +++

CEUS ++

CT +

MRI +

HHT

III/post-partum

Pain, liver failure, bleeding

Liver infarction, aneurysm rupture

Surveillance and diagnosis of complications

US ++

CT + (+++ if complications)

MRI +

Cirrhosis

Any

Decompensation, worsening portal hypertension, variceal bleeding

Ascites, focal liver lesions assessment, portal hypertension

Surveillance, assess complications, treatments (TIPS)

US +++

CEUS ++ (if lesions)

MRI ++ (if lesions)

Focal Hepatic Masses

Any

Abdominal tension or pain / Asymptomatic

Growth +/- bleeding and liver rupture

Detect and characterize

US ++

CEUS ++

MRI ++

CT + (only if cancer)

Cholelithiasis

Any

Right upper quadrant pain, nausea

Gallstones, pancreatitis, ductal dilatation

Diagnosis

US +++

MRI ++

Hepatitis

Any

Nausea, inconstant jaundice, liver dysfunction

Hepatomegaly, gallbladder wall thickening, diffuse hepatic hypoechogenicity // small hypoechoic lesions

Differential diagnosis and confirmation of diagnosis

US +++

CT +

MRI ++

Abscesses

Any

Fever, nausea, pain

Avascular, thick-walled fluid collection, perfusion disorders

Diagnosis and guidance of treatment

US +++

CT +

MRI ++

Liver transplantation

2nd half of pregnancy //post-partum

Pre-eclampsia and HELLP syndrome

Infarct, hemorrhage, hematoma, liver rupture

Assess complications as soon as possible

US +++

CT (when complications) +++

  1. Abbreviations: ICP intrahepatic cholestasis of pregnancy, AFLP acute fatty liver of pregnancy, HELLP hemolysis, elevated liver enzymes, low platelet, HHT hereditary hemorrhagic telangiectasia, TIPS trans-jugular intrahepatic portosystemic shunt, US ultrasonography, CEUS contrast-enhanced US, CT computed tomography, MRI magnetic resonance imaging, MRCP magnetic resonance cholangiopancreatography. Indication for imaging techniques is scored from + to +++