Fig. 5
From: Multiparametric MRI evaluation of bone sarcomas in children
Ewing sarcoma involving the proximal left humerus in a 12-year-old boy. a Sagittal contrast-enhanced fat-suppressed T1-weighted MR image shows a heterogeneous mass centered in the proximal humeral metaphysis (*) that extends to the epiphysis and proximal diaphysis and contains foci of internal necrosis (short arrow). Note severe varus angulation of the humerus due to previous fracture (long arrow). b Axial ADC MR image shows restricted diffusion of the cellular areas (*) with no restriction of the necrotic foci (arrow). c Sagittal contrast-enhanced fat-suppressed T1-weighted MR image after treatment shows decrease in volume of the mass with increase of necrotic areas (arrows). d Axial ADC MR image after treatment shows no restricted diffusion (*). e Volumetry of ADC maps performed before treatment shows a high and sharp ADC histogram of 0.7 mm2/s, while the histogram after treatment is short and wide and shifted to the right, with a value of 1.9 mm2/s. The conventional MRI sequences together with DWI indicate good treatment response