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Ultrasound-guided core-needle biopsy of breast lesions



To review the role of ultrasound-guided core-needle biopsy (CNB) in the management of breast lesions.


Review of the most relevant literature on this topic.


This technique shows a high sensitivity value of about 97.5% and it offers many advantages over other imaging techniques to guide a biopsy: non-ionising radiation, low cost, full control of the needle in real time, accessibility in difficult locations, multidirectional punctures and excellent comfort for patients and radiologists. All of these advantages have made this technique the most widespread used to perform a biopsy for a suspicious breast lesion. The most important limitation is the failure to perform a biopsy for lesions that are not seen on ultrasound. An adequate radiological–pathological correlation is necessary to minimise the false-negative results.


Ultrasound-guided CNB has proven to be a reliable technique for performing a biopsy for breast lesions that can be clearly seen on ultrasound.


Nowadays, percutaneous imaging-guided breast biopsy is a reliable alternative to surgical biopsy for a histological diagnosis [15]. Percutaneous biopsy is less invasive than surgery, can be performed quickly, does not deform the breast, causes minimal scarring, complications (haematoma and infection) are infrequently found (less than one case in 1,000), fewer surgeries are needed for patients who undergo percutaneous biopsies and therefore the cost of diagnosis is lower [15].

There are two main objectives of percutaneous biopsy techniques: first, achieving the maximum degree of accuracy and second, offering as much information as possible about the tumour (type, grade, invasion, hormonal receptors, HER-2 NEU, etc.). To achieve these objectives, the percutaneous biopsy devices have evolved, from fine-needle aspiration cytology towards core-needle biopsy (CNB) and later vacuum-assisted biopsy (VAB) [1]. Nowadays, ultrasound-guided core needle breast biopsy has become the first choice for performing a percutaneous biopsy for most lesions seen on ultrasound [1, 69]. Virtually any breast lesion that is clearly seen on ultrasound can be sampled under ultrasound guidance [6]. Many surgical biopsies that had to be carried out in the past, because of suspicious radiological findings, are nowadays unnecessary due to the extensive use of ultrasound NCB. In addition, surgical specimens removed after a previously proven malignant result are usually more adequate for the tumour size. Consequently, the number of surgical procedures has also been reduced for malignant lesions. Thus, the number of surgical procedures has drastically decreased both for benign and malignant lesions, thanks to the extensive use of ultrasound CNB and the other methods of percutaneous biopsy.

The technique was first described by Parker and co-workers in the early 1990s, and nowadays ultrasound CNB has become the first choice for performing most breast biopsies [2, 4, 5, 9].

Advantages and limitations of ultrasound NCB

The numerous advantages of ultrasound guidance over stereotactic and MR guidance have been key in explaining the widespread use of this technique. Noteworthy among these advantages are:

  • Ultrasound involves non-ionising radiation.

  • Full control of the needle position in real time. Neither stereotactic guidance nor MR guidance offers this advantage.

  • Ultrasound equipment is cheaper and more readily available than stereotactic or MR units.

  • Accessibility of difficult places, such as the axilla or near the nipple. These are limitations for stereotactic or MR guidance.

  • Multiple lesions (unilateral or bilateral) can be safely biopsied in one session, usually more quickly than with other imaging techniques.

  • The breast is not compressed.

  • Excellent comfort for patients and radiologists, although stereotactic prone tables are also comfortable for both.

  • Local anaesthesia and haematoma do not hide the lesion (non-calcified masses can be obscured with use of stereotactic equipment). However, bubbles injected with the local anaesthesia can obscure the lesion.

  • It is a cost-effective technique: Liberman et al. [8] found that ultrasound CNB yielded a 56% decrease in the cost of diagnosis. For masses amenable to either stereotactic or ultrasound guidance, cost savings are greater if the biopsy is performed under ultrasound guidance [8]. According to Schueller et al. [10], overall cost savings for ultrasound CNB over surgical biopsy were 977 euros [10].

The main disadvantage of ultrasound CNB is the limitation of performing a biopsy for lesions not seen on ultrasound. Most clustered microcalcifications, especially if they are not inside a mass, cannot be identified on ultrasound. However, high-resolution transducers can demonstrate some clustered microcalcifications even in the absence of a mass.

Although most ultrasound CNB procedures are easy to perform, in some special situations (deeply located lesions, patients with implants, axillary lesions, etc.) a high level of experience is needed to get reliable results.

Current indications and contraindications

All lesions classified as BI-RADS 4 and 5, clearly visible on ultrasound, are amenable to ultrasound CNB [6]. This technique can also be used for some BI-RADS 3 lesions under certain circumstances: genetic or family risk, medical or social difficulties for follow-up, pregnancy, extreme anxiety and others, including the patient’s decision.

Ultrasound CNB can be difficult in patients with severe psychiatric disorders, which makes them impossible to collaborate on, and is contraindicated in some cases of severe blood dyscrasia. However, there are no statistically significant differences in haematoma formation between patients taking anticoagulant therapy daily and non-treated patients [11]. Thus, it is not necessary to stop that therapy to perform an ultrasound CNB. Expert radiologists can perform biopsies of very deep lesions located close to the pectoral muscle in large breasts. Obtaining a biopsy in some patients with silicone implants can be also contraindicated.

Palpable lesions can be safely biopsied under ultrasound guidance. Although surgeons have been using CNB guided by palpation for a long time [12], the accuracy is increased with ultrasound guidance [13].

As well as diagnostic objectives, ultrasound guidance allows us to perform other interesting therapeutic procedures such as evacuation of liquid or semi-solid collections and placement of markers or coils for neoadjuvant chemotherapy. More recently, ultrasound guidance has been useful for tumour ablation using radiofrequency, cryoablation, laser therapy or focused ultrasound [1416].

Technical procedure

There is a wide spectrum of core-needle devices that can be used under ultrasound guidance (Fig. 1). The thickness of the needles can be selected, varying from 18- to 8-gauge; however, 14-gauge conventional Tru-cut devices have been the most commonly used [6]. Nowadays there is a trend towards using 10- to 11-gauge vacuum-assisted devices.

Fig. 1
figure 1

A small sample of the great variety of biopsy devices that can be used under ultrasound guidance

It is very important to correlate mammography, ultrasound and MRI findings, in order to carry out the puncture using the most suitable method of guidance. Sometimes it is necessary to perform several biopsies in the same patient using different techniques of imaging guidance (i.e. microcalcifications under stereotactic guidance and a mass, only visible on ultrasound, under ultrasound guidance). Metallic markers can be placed superficially on the skin close to the lesion or inside the lesion to correlate ultrasound and mammography findings.

The use of high-frequency (10- to 12-MHz) probes, adjustments in the dynamic range and postprocessing grey scales, as well as correct focus, are important to improve the visibility of breast lesions.

The patients should have a complete, thorough level of information about the technique, indications, contraindications, complications and alternative possibilities; therefore, obtaining informed consent is mandatory. Local anaesthesia must be injected superficially and also as deeply as necessary, under sterile conditions. This anaesthesia does not mask the lesion and sometimes can help us to move it to another, more accessible place, deeper or more superficial. However, bubbles mixed with the anaesthesia can mask the lesion; thus, they must be avoided.

After localising the lesion with ultrasound, the procedure is performed in an outpatient setting, using the free-hand technique: one hand holds the probe and the other hand holds the needle (Fig. 2). One of the main advantages of ultrasound-guided CNB is the full control of the needle position in real time, allowing for corrections in the needle direction.

Fig. 2
figure 2

These pictures illustrate how the ultrasound CNB procedure is performed. a Local anaesthesia is injected, b a small incision is required and c the biopsy device is guided by ultrasound

As a general rule, the shortest route from the skin to the lesion should be used. A vertical approach would be the best, but it is not possible under ultrasound guidance. However, an oblique approach, as parallel to the chest wall as possible, should be used (Fig. 3). This is the way to avoid pneumothorax, the worst complication of this technique. This approach also enables the best visualisation of the needle, because even large-gauge needles are difficult to visualise if a steep angle is used because of less reflective echoes. However, when the needle is parallel to the probe, the number of needle-generated reflected echoes that are perpendicular to the ultrasound beam is maximised, so the needle can be identified. This horizontal approach can be used to perform a biopsy for cutaneous lesions (Fig. 4).

Fig. 3
figure 3

The approach to the lesion should be as parallel to the chest wall as possible to avoid pneumothorax. Moreover the transducer should be orientated parallel to the needle in order to facilitate the needle visualisation

Fig. 4
figure 4

An ultrasound CNB is performed in this cutaneous metastasis (arrows). Note the horizontal approach needed in this case

It is useful to move the patient to lateral decubitus positions, especially in the case of deeply located lesions or peripheral masses. If possible, an approach through fat is preferable, because the puncture is easier (the fat is soft and the needle can be easily guided; Fig. 5).

Fig. 5
figure 5

A puncture through a fat lobule is easier than through fibrous dense tissue

It is important to insert the tip of the needle inside the mass, because there is a dead space behind the tip. If the tip is not inserted, then part of the specimen will not belong to the lesion but to the perilesional tissue, and there is a risk of lancing the lesion, especially if it is very hard. Necrotic tissue inside the lesion should not be targeted. Pre-fire and post-fire images are important to ensure the correct position of the needle and to rule out the occurrence of complications (Fig. 6).

Fig. 6
figure 6

One of the main advantages of ultrasound CNB is the full control of the needle direction in real time. Pre-fire and post-fire images are useful to ensure the correct position of the needle

In the case of very dense breasts, the punction can be difficult. There are some tricks that can be used:

  • Coaxial technique: once the coaxial needle is inserted in the lesion, the inner trocar can be removed and replaced by the biopsy needle [6].

  • A 16-gauge needle instead of a 14-gauge one. The smaller diameter, the lower friction with the surrounding tissue. The punction is easier and the strength of the shot is greater.

  • Stronger devices, such as vacuum-assisted devices.

  • Devices with diamond-shaped needle tips, because they transverse the fibrous tissue better than conventional needles (Fig. 7).

Fig. 7
figure 7

Diamond-shaped needle tips are better than conventional ones to traverse the fibrous tissue

In the case of deeply located lesions there is a need to use a parallel approach to the chest wall, so that this structure is not penetrated and pneumothorax is avoided. Other tricks that can be used include:

  • The needle can be used as a lever: the entry of the needle has to be located about 2 cm from the edge of the transducer and the lesion is manually lifted away from the chest wall [6].

  • Local anaesthesia can be used to move the lesion to a more convenient place, especially if it is injected deep to the lesion (Fig. 8).

Fig. 8
figure 8

The injection of local anaesthesia below the lesion can move it to a more superficial position

The macroscopic evaluation of the specimens is also important, because it can give additional information about their quality: colour, consistency and grade of immersion of the cylinders in formaldehyde can be useful criteria for knowing their suitability for diagnosis. Intact, white or brown samples that quickly sink are considered more representative and are consequently preferred to fragmented, floating yellow ones, normally containing only adipose tissue [17]. This is the first index of correlation; of course it is not conclusive, but only orientative (Fig. 9). If the biopsied lesion is a cluster of microcalcifications, a specimen radiograph is mandatory to confirm the presence of microcalcifications (Fig. 10).

Fig. 9
figure 9

White specimens that sink are usually more representative than floating yellow specimens

Fig. 10
figure 10

Specimen radiograph showing microcalcifications. The radiograph was taken in a digital mammographic unit (Inspiration, Siemens, Erlangen, Germany) at 23 KV and 9 mAs. The cylinders were collected into a plastic cassette

Four specimens may be enough for a reliable diagnosis, according to Fishman et al. [17]. However, other authors find a diagnosis with only two specimens to be reliable [18].

Vacuum-assisted biopsy devices under ultrasound guidance have been used as an alternative to conventional ultrasound CNB. When VAB is performed, more specimens are removed [19].

However, Philpotts et al. [20] compared the two techniques (181 CNB procedures vs 100 VAB procedures) and found no significant differences in false-negative results, underestimation and complications. The reason for such a result is probably the homogeneity of most ultrasound-detected lesions (a small specimen is representative of the whole lesion) and the low frequency of borderline results (such as atypical ductal hyperplasia and others, which are usually associated with microcalcifications and are not seen on ultrasound).

However, the number of samples should be greater for those lesions with complex radiological features. In these cases, for example parenchymal distortions or asymmetric densities, more samples and/or thicker needles are recommended. The first cylinders are the most important ones, because later the suspicious lesion can be masked by variable degrees of bleeding.


After the initial results by Parker and co-workers, with a 100% correlation with surgical results for 49 excised masses and no additional cancers in the remaining 132 cases, all the published series have shown excellent results (Table 1) [710, 17, 2126]. Sensitivity of ultrasound-guided CNB is about 97.5%, which makes this technique a very good choice for performing a breast biopsy. In published series 10% of lesions required repeat biopsy, 17% of which had malignancy [27]. Most of the cancers that were not initially diagnosed were biopsied again after new evaluation. Radiological–pathological correlation is the clue to diagnosing those missed cancers. Therefore, the correlation between radiological and histological findings is very important.

Table 1 Results for breast ultrasound-guided CNB series

Radiological–pathological correlation

Despite performing an optimised biopsy procedure, a false-negative result can occur. In the case of microcalcifications, the specimen radiograph is very useful for confirming them in the removed tissue. However, the specimen radiograph does not give additional information on non-calcified lesions. Post-biopsy mammography usually shows no substantial alteration in the target lesion with conventional 14-gauge needles. Therefore, the radiological–histological correlation is crucial to avoid false-negative results.

Five situations of radiological–histological correlation can occur [28]:

  • Concordant malignancy: a lesion that is radiologically suspicious for malignancy (BI-RADS category 4 or 5) is histologically diagnosed as malignant after core biopsy (B4 or B5). Adequate treatment should be performed.

  • Discordant malignancy: a radiologically benign lesion (BI-RADS 2 or 3) is finally diagnosed as histologically malignant after core biopsy (B4 or B5). Adequate treatment should be performed.

  • Concordant benignity: the radiological findings are benign or low–intermediate suspicious (BI-RADS 2, 3, 4a, 4b), and histological features are benign (B1 or B2 categories). An adequate radiological–pathological correlation should be established, and imaging follow-up should be offered to avoid delayed false-negative results. Exceptionally, some of these lesions can be surgically or percutaneously excised because of patient anxiety, patient decision or physician preference.

  • Discordant benignity: a radiologically malignant lesion (BI-RADS category 4c or 5) is proved to be benign after core biopsy. In this case, both the imaging and the pathological findings should be reviewed again. It is imperative to find a diagnosis; therefore, a new percutaneous biopsy (including vacuum-assisted breast biopsy) or a surgical removal can be offered.

  • Borderline findings: atypical ductal hyperplasia, lobular neoplasm, radial scar, papillary lesion and phyllodes tumour, are classified as B3 pathological results and usually require the removal of the whole lesion. It has been demonstrated that the rates of underestimation decrease as the number and calibre of samples increase [29]. In cases of atypical ductal hyperplasia or radial scar with atypia, a surgical biopsy is probably the best option because it is possible to find histological features of ductal carcinoma in situ or even invasive carcinoma in the surrounding tissue.


The complications of ultrasound CNB are infrequent and not significant. Both haematomas and infections are very rare, accounting for less than 1/1,000 biopsies [5], being similar to the complications of other percutaneous biopsy devices. The possibility of pneumothorax exists [30], but it is very rare using the free-hand technique and a horizontal approach. Patients should be informed about the possible complications of the technique.

One complication of all percutaneous biopsies is epithelial displacement. It was first described by Harter et al. [31] in 1992. In 1999, Diaz et al. [32] concluded that epithelial displacement was seen in up to 37% of all biopsies. However, the displaced cells did not seem to be viable. Later, in 2002, Chen et al. [33] compared the recurrences after percutaneous biopsies vs surgical biopsies in patients with breast-conserving therapy, and found no significant differences in recurrence rates. Thus, whatever the method of biopsy, the recurrence rate was similar.


All BI-RADS 4 and BI-RADS 5 lesions, and some BI-RADS 3 ones, should be percutaneously punctured, and in cases with benign results, surgery can be avoided if there is a good radiological–pathological correlation and no borderline result is obtained. Ultrasound CNB is a well-known, safe and accurate technique that is currently considered the elective method, whereas stereotaxy and MRI should be reserved for lesions that are not clearly seen on ultrasound. Complications are infrequent and not serious.

For these reasons, we would encourage all breast radiologists to gain plenty of experience of this technique.


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Correspondence to Luis Javier Pina.

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Apesteguía, L., Pina, L.J. Ultrasound-guided core-needle biopsy of breast lesions. Insights Imaging 2, 493–500 (2011).

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  • Core needle
  • Biopsy
  • Ultrasound guided
  • Breast