- Pictorial Review
- Open Access
Pseudotumoural soft tissue lesions of the foot and ankle: a pictorial review
© European Society of Radiology 2011
- Received: 29 October 2010
- Accepted: 15 February 2011
- Published: 1 May 2011
In the foot and ankle region, benign neoplasms and pseudotumoural soft tissue lesions are significantly more frequent than malignant tumours. The pseudotumoural lesions constitute a heterogeneous group, with highly varied aetiology and histopathology. This article reviews the imaging features of the most common pseudotumours of the soft tissues in the foot and ankle. Although the imaging characteristics of several of the lesions discussed are non-specific, combining them with lesion location and clinical features allows the radiologist to suggest a specific diagnosis in most cases.
- Soft tissue
Soft tissue lesions of the foot and ankle are a relatively rare cause of referral for medical imaging. They include benign and malignant neoplasms, as well as non-neoplastic or pseudotumoural lesions. In the foot, only a small number of soft tissue lesions prove to be malignant. Synovial sarcoma, clear cell sarcoma, leiomyosarcoma, fibrosarcoma and malignant fibrous histiocytoma are the most frequent malignancies. Benign tumours include deep fibromatosis, neurogenic tumours, lipoma, haemangioma and synovial proliferations (pigmented villonodular synovitis—giant cell tumour of the tendon sheath and synovial osteochondromatosis). The pseudotumoural lesions of the foot comprise a diverse group with widely varying histopathology; they include, among others, ganglion and synovial cysts, intermetatarsal and adventitious bursitis, epidermoid cysts, inflammatory lesions (gout tophi and rheumatoid nodules), Morton’s neuroma and granuloma annulare. Aetiopathogenesis of these lesions is varied, but, in general, degenerative, inflammatory and infectious phenomena may play a role. The aim of this article is to give a comprehensive overview of the most common pseudotumoural lesions of the foot and their respective imaging features.
Ultrasound shows a hypoechogenic structure with a typical striated appearance of muscle. Dynamic ultrasound with active muscle contraction will show changes in the shape of the mass. On magnetic resonance (MR) imaging, accessory muscles are isointense to other muscle tissue on all pulse sequences .
The terminology of these cystic lesions is confusing, and in clinical practice the terms “synovial cyst” and “ganglion cyst” are sometimes used interchangeably.
The term “synovial cyst” describes a continuation or herniation of the synovial membrane through the joint capsule. It consists of a fluid collection, lined by a continuous layer of “true” synovial cells. There is always communication with the adjacent joint. Usually, associated joint disease is present, like osteoarthrosis, inflammatory and post-traumatic joint diseases.
A ganglion cyst also contains a mucinous fluid, but the wall consists of a discontinuous layer of flattened pseudosynovial cells, surrounded by connective tissue. Communication with the adjacent joint is not always present. There remains much controversy in the literature concerning the pathogenesis of ganglion cysts. According to the synovial herniation theory, a ganglion cyst represents an advanced stage of a degenerated synovial cyst, in which the continuous synovial lining and the communication with the joint may be lost during the process of degeneration .
Ganglion and synovial cysts are the most common soft tissue lesions in the ankle and foot region, most frequently located around the ankle or at the dorsum of the foot. In the ankle and foot region, they are more frequently associated with symptoms similar to those of lesions at the wrist . Clinically, local pain, limited joint mobility or nerve entrapment (e.g. in the tarsal tunnel) may be present due to mass effect .
The role of imaging is to define the cystic nature and exact location of the lesion, and to demonstrate possible communication with a joint or tendon sheath, which is relevant for optimal treatment planning.
Even with MR imaging, identification of a communicating stalk with the joint or tendon sheath may be difficult. In these cases, CT arthrography with delayed imaging may be performed to ultimately demonstrate communication .
Morton’s neuroma, or interdigital neuroma, is, despite its name, not a true neuroma but perineural fibrosis and nerve degeneration , most likely due to repetitive compression and irritation of the interdigital nerve. Therefore, the term Morton’s fibroma is preferred. Morton’s fibromas are most commonly found in the second and third intermetatarsal spaces, and less frequently in the first and fourth. Also, more than one intermetatarsal space may be affected.
Morton’s fibroma is most commonly diagnosed in middle age, with a higher prevalence in women, and is believed to be related to the use of high-heeled shoes with increased weight bearing on the forefoot .
Although Morton’s fibroma is a common cause of intermetatarsalgia, in many cases it is not associated with clinical symptoms. Lesions with a transverse diameter smaller than 5 mm are often asymptomatic, as studies on healthy volunteers have shown, with a prevalence of small (<5 mm) Morton’s fibromas of approximately 30% in asymptomatic individuals . Lesions with a transverse diameter of 5 mm or more are most likely symptomatic. When a smaller lesion is detected, it might not be the cause of the patient’s symptoms, and other pathological conditions (e.g. intermetatarsal bursitis, stress fracture, true neuroma) should be excluded .
Ultrasound examination is reliable in detecting Morton’s fibroma  and evaluation reveals a well-defined hypo-echoic mass in the plantar soft tissues at the level of the metatarsal heads. However, distinction of Morton’s fibroma from an accompanying enlarged intermetatarsal bursa can be difficult, and lead to an overestimation in size . Dynamic ultrasound examination using Mulder’s test can increase conspicuity and diagnostic confidence. For this test, the patient’s forefoot is held in the sonographer’s non-imaging hand while performing lateral compression of the metatarsals, and applying the transducer to the plantar aspect of the intermetatarsal regions. When this manoeuvre is performed on patients with a Morton’s fibroma, the mass is compressed between the metatarsal heads eliciting characteristic pain before it is plantarily displaced, often coinciding with a palpable click (Mulder’s sign). This displacement allows ultrasound visualisation of otherwise occult lesions as well as more reliable measurement of small lesions .
MR imaging has been proven to be highly sensitive and specific in diagnosing Morton’s fibroma, as well as providing an accurate preoperative assessment .
Inflammation of the intermetatarsal bursae is a known cause of metatarsalgia. The intermetatarsal bursa is a naturally occurring synovium-lined cavity between the metatarsal heads containing a small amount of lubricating fluid, located immediately dorsal to the deep transverse metatarsal ligament. This bursa is normally present in the first through fourth intermetatarsal space . Studies in asymptomatic volunteers have shown that demonstration of a small amount of fluid in the bursae of the first through third intermetatarsal space on MR imaging cannot be considered a sign of bursitis. A transverse diameter greater than 3 mm of these bursae has been proposed as a cut-off value for suggesting intermetatarsal bursitis. However, demonstration of fluid in the fourth intermetatarsal space always appears to be connected to clinical symptoms .
Although the exact pathogenesis of intermetatarsal bursitis is unclear, it is thought to be the result of chronic mechanical compression and irritation between the metatarsal heads, similar to the suspected pathogenesis of Morton’s neuroma . It is thus unsurprising that these disorders are frequently associated (Fig. 5).
MR imaging demonstrates a well-defined fluid collection at a typical location between the metatarsal heads with low SI on T1-WI and high SI on T2-WI. Subtle peripheral enhancement is seen following intravenous administration of gadolinium contrast medium .
Adventitious bursae may develop in adulthood at sites where subcutaneous tissue is exposed to high pressure and friction . Under these conditions formation of a subcutaneous adventitious bursa starts as a coalescence of pre-existing small spaces in loose connective tissue. The walls progressively become differentiated from the adjacent connective tissue and a well-defined fluid-filled cavity is formed, which is lined by synovium-like columnar cells . Unlike permanent bursae, which serve to reduce friction between skin and adjacent bony protuberances (e.g. over the olecranon), they lack a mesothelial lining .
In the foot and ankle, adventitious bursae may develop almost anywhere, usually adjacent to bony prominences. The most common locations are over the medial aspect of the first metatarsal head and plantar to the metatarsal heads.
Although plantar fat pad alterations under the first and fifth metatarsal heads are a common incidental finding on MR imaging in asymptomatic volunteers, these are smaller than those in symptomatic individuals. These asymptomatic alterations are of low SI on T1-WI and T2-WI, and are believed to represent reactive fibrous tissue induced by mechanical stress (see “Miscellaneous disorders—Diabetic callus”) .
An epidermoid cyst results from the proliferation of keratin-producing epidermal cells within a circumscribed space of the dermis. Histologically, an epidermoid cyst appears as a keratin-containing cyst lined with surface epidermis. The source of this epidermis is nearly always the infundibulum of a hair follicle .
Epidermoid cysts are, therefore, most common in the hair-bearing parts of the body, such as the scalp, face, trunk and scrotum. Occurrence in the extremities is less frequent, and thought to be due to traumatic implantation of epidermal tissue in the dermis. As a consequence, the most common location in the foot is at the plantar or medial aspect of the first metatarsal head .
If an epidermoid cyst ruptures, the cyst contents are released into the dermis, with formation of a keratin granuloma . Ruptured epidermoid cysts tend to present as multilocular lesions, with enhancement of the cyst wall due to fibrosis and giant-cell reaction to keratin, possibly mimicking malignancy .
Granuloma annulare (GA) represents a group of benign dermatoses of unknown aetiology which include cutaneous (localised, generalised or perforating) and subcutaneous types. This last type is referred to as subcutaneous granuloma annulare (SGA), occasionally also referred to as pseudorheumatoid nodule.
Histologically, SGA consists of a palisading granuloma with a small area of central necrosis .
The SGA is most common in otherwise healthy children between the ages of 2 and 5 years, but it can occur at any time from infancy to young adulthood .
Typically, it presents as a painless, immobile, solitary mass on the lower extremities, with normal overlying skin. Other, less frequent locations are upper extremities, buttocks, face and scalp. SGA will spontaneously regress without treatment and does not require biopsy or diagnostic imaging in clinically apparent cases. However, because of the subcutaneous location, clinical diagnosis can be difficult for non-dermatological specialists , which can result in a request for diagnostic imaging of a non-specific soft tissue mass.
The most important clues for the radiologist to suggest SGA on MR imaging are the patient’s age, location limited to subcutaneous tissue, indistinct lesion margins, and the previously mentioned signal characteristics on MR imaging. However, as imaging characteristics are non-specific, making the correct diagnosis in the absence of cutaneous abnormalities requires a biopsy.
Rheumatoid nodules are granulomatous lesions with central areas of necrosis that occur in about 20% of patients with rheumatoid arthritis and less frequently in patients with rheumatic fever, systemic lupus erythematosus and ankylosing spondylitis .
These nodules can occur in the subcutaneous tissues in areas susceptible to trauma and in tissue overlying bursae, joints, tendons or ligaments. They are most common along the extensor side of the upper extremity. Less frequently they occur in the foot, typically at pressure points such as the heel pad and under the metatarsal heads.
Diagnosis can be suggested if associated MR signs of inflammatory joint and bone disease are present (e.g. erosions, joint destruction, bone marrow oedema).
Tenosynovitis involves inflammation of the tendon sheath. The aetiology may include acute and chronic trauma, infection or inflammatory or metabolic disease. Excessive fluid accumulation in the tendon sheath can sometimes lead to a mass-like presentation .
Ultrasound examination reveals an effusion in the tendon sheath, along with thickening of the synovial lining. Doppler signals in the synovium and the adjacent soft tissues may be increased .
Tophaceous gout is a pseudotumoural process that usually manifests in later stages of gout arthritis. A gouty tophus is an amorphous or crystalline mass of urate with a surrounding layer of inflammatory tissue . Lesions typically occur at the metatarsophalangeal or interphalangeal joints . In rare cases extensive tophaceous gout can result in multiple soft tissue masses with destruction of multiple bones of the foot .
Clinical history, laboratory examination and radiographic findings will usually steer the clinician to the correct diagnosis of tophaceous gout, but occasionally a gouty tophus can mimic a neoplastic or infectious process, for which the referring clinician requests imaging studies.
On contrast-enhanced MR images, gouty tophi typically display a moderate to marked heterogeneous or near-homogeneous enhancement .
Tumoral calcinosis is a disease characterised by lobular, calcified soft tissue masses that occur in periarticular locations, especially the hip, elbow, shoulder, foot and wrist. The masses are often multiple and bilateral .
Tumoural calcinosis is usually classified as primary (idiopathic or familial) or secondary. The primary form typically presents with soft tissue masses in the first or second decade of life, whereas the secondary form occurs mainly in patients with chronic renal failure, and has been attributed to secondary hyperparathyroidism .
On radiographs, tumoural calcinosis appears as multilobulated calcific deposits in a periarticular distribution, usually along the extensor surfaces of joints. The calcified masses may have a dense appearance or may contain fluid-calcium levels, known as the “sedimentation sign” . Occasionally, pressure erosion on the underlying bone is seen .
MR examination is not required to make the diagnosis. If it is performed, tumoural calcinosis appears as a pseudotumour in periarticular regions with large septated regions of variable SI on both T1-WI and T2-WI .
Other metabolic disorders
Amyloidosis in rare cases results in the formation of pseudotumoural lesions at the foot and ankle. Amyloid deposition within the joint capsules or in the dermis can occasionally present as a soft tissue mass [53, 54]. Characteristically, the amyloid has a low SI on T1-WI, and a low to intermediate SI on T2-WI .
Tophaceous pseudogout caused by periarticular tumoural calcium pyrophosphate dehydrate (CPPD) or calcium hydroxyapatite (HA) deposition can occasionally mimic soft tissue or skeletal lesions . On conventional radiography, the tophaceous lesions demonstrate calcification in a more granular and delicate pattern than the lobular-appearing calcification of tumoural calcinosis. On MR imaging, signal intensities of pseudogouty tophi can vary from low to intermediate on T1-WI and from low to high on T2-WI. Often areas of low signal are seen, corresponding to calcifications .
Soft tissue callus is a superficial soft tissue thickening that forms in response to mechanical pressure. Although benign and fairly common in the adult population, it occurs more often and builds up faster on the feet of diabetic patients. It develops in areas of abnormal weight-bearing and friction caused by diabetic foot deformities, and can eventually lead to ulceration and deeper infection.
Callus is commonly seen in the subcutaneous fat plantar to the first and fifth metatarsal heads.
Stress reaction and fracture
Post-traumatic bone abnormalities such as stress reactions and fractures may mimic a tumoural lesion of the ankle or foot. A clinical history of a professional sporting activity or daily activity with increased stress on foot and/or ankle may aid in the diagnosis of such lesions.
Stress reaction in soft tissues around the ankle presenting as a tender mass has been described in figure skaters and professional snow boarders at the level of the shoe rim . On MR imaging, these lesions appear as ill-defined mass-like regions iso-intense to muscle on T1-WI, with increased SI on T2-WI and enhancement after intravenous gadolinium contrast medium administration.
Myositis ossificans (MO) is a benign condition of heterotopic bone formation, which can mimic soft tissue malignancy. It is very rarely seen in the foot and ankle region [63, 64]. Late-stage lesions display a zonal ossification pattern making diagnosis possible with conventional radiography . Detailed discussion of the imaging features of MO is beyond the scope of this short review.
Plantar fibromatosis (Ledderhose disease)
The aetiology of plantar fibromatosis is still a matter of debate, but it is thought to represent a benign fibroblastic tumour, rather than a pseudotumour. Patients present clinically with painless, fixed, subcutaneous nodules on the sole of the foot, along the course of the plantar aponeurosis.
As plantar fibromatosis is considered to of a tumoural nature, detailed discussion of this entity and its imaging features is beyond the scope of this review.
The imaging features of pseudotumoural soft tissue lesions of the foot and ankle themselves are often non-specific, but in combination with exact location, the relationship with surrounding structures and clinical features such as sex, age and symptoms, the radiologist can usually suggest a specific diagnosis. The goal of imaging in the setting of pseudotumoural lesions is thus to confidently identify lesions that do not need further investigations and/or interventions (e.g. biopsy).
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