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Table 2 Two hundred six patients’ univariate and multivariate logistic regression analysis

From: Predicting microvascular invasion in small (≤ 5 cm) hepatocellular carcinomas using radiomics-based peritumoral analysis

Variant

Univariate

Multivariate

 

OR (95%CI)

p value

OR (95%CI)

p value

Gender

 Male vs female

0.337 (0.112, 1.014)

0.053

  

Age

60 vs < 60 years

1.287 (0.680, 2.438)

0.438

  

AFP (ng/mL)

 < 20 vs 20

1.586 (0.866, 2.906)

0.135

  

Pathology grade

 I–II vs III–IV

1.810 (0.919, 3.563)

0.086

  

Capsular invasion

 No vs yes

5.673 (2.020, 15.934)

0.001*

6.658 (2.054, 21.578)

0.002*

Tumor size

2 cm vs > 2 cm

1.656 (0.710, 3.865)

0.243

  

Hepatitis B

 No vs yes

0.616 (0.278, 1.363)

0.232

  

Hepatitis C

 No vs yes

0.998 (0.630, 1.581)

0.994

  

Cirrhosis

 No vs yes

0.546 (0.288, 1.035)

0.064

  

Budd-Chiari syndrome

 No vs yes

3.147 (0.815, 12.150)

0.096

  

Preoperative ALT

40 U/L vs > 40 U/L

1.950 (1.044, 3.642)

0.036*

  

Preoperative AST

40 U/L vs > 40 U/L

1.884 (1.015, 3.496)

0.045*

  

Child–Pugh score

 A vs B–C

0.657 (0.207, 2.082)

0.475

  

Hepatic encephalopathy

 No vs yes

    

Ascitic fluid

 No vs yes

1.868 (0.620, 5.634)

0.267

  

Total protein

25 vs > 25 μmol/L

1.907 (0.820, 4.433)

0.134

  

Albumin

 35–55 μmol/L vs < 35 or 55 μmol/L

1.199 (0.592, 2.427)

0.614

  

Peritumoral enhanced

 Yes vs no

6.252 (2.841, 13.759)

0.000*

3.911 (1.583, 9.664)

0.003*

Smooth edge

 Yes vs no

0.217 (0.113, 0.416)

0.000*

  

Complete capsule

 Yes vs incomplete and no

0.217 (0.112, 0.421)

0.000*

0.447 (0.206, 0.972)

0.042*

Intratumoral arteries

 Negative vs positive

3.221 (1.722, 6.024)

0.000*

  

Peritumoral low density

 Negative vs positive

0.192 (0.072, 0.512)

0.001*

  

Tumor-liver difference

 Clear vs unclear

0.230 (0.119, 0.446)

0.000*

0.306 (0.142, 0.659)

0.002*

TTPVI

 Negative vs positive

5.067 (2.575, 9.971)

0.000*

2.368 (1.074, 5.223)

0.033*

RVI

 Negative vs positive

9.130 (3.146, 26.500)

0.000*

  
  1. RVI radiogenomic venous invasion, TTPVI two-trait predictor of venous invasion
  2. *p < 0.05