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Table 2 Univariate analysis for the variables of clinic, radiology and DECT for differentiating between low and high Ki-67 expression sets in the training cohort

From: Development and validation of a model for predicting the expression of Ki-67 in pancreatic ductal adenocarcinoma with radiological features and dual-energy computed tomography quantitative parameters

Variables

Low Ki-67 expression set (Ki-67 ≤ 50%, n = 77)

High Ki-67 expression set (Ki-67 > 50%, n = 23)

F/Z/χ2

value

BMI

22.40 ± 2.84

22.00 ± 2.50

2.112

0.538

CEA (%)

  

0.337

0.562

 Normal

52 (67.5)

17 (73.9)

  

 Elevated

25 (32.5)

6 (26.1)

  

CA-125 (%)

  

0.978

0.323

 Normal

49 (63.6)

12 (52.2)

  

 Elevated

28 (36.4)

11 (47.8)

  

CA-199 (%)

  

3.391

0.066

 Normal

19 (24.7)

1 (4.3)

  

 Elevated

58 (75.3)

22 (95.7)

  

Tumour location (%)

  

0.325

0.568

 Head and neck

55 (71.4)

15 (65.2)

  

 Body and tail

22 (28.6)

8 (34.8)

  

CT-reported T stage (%)

  

0.076

0.782

 T1–T2

41 (53.2)

13 (56.5)

  

 T3–T4

36 (46.8)

10 (43.5)

  

CT-reported regional LN status (%)

  

10.36

 < 0.001

 Negative

45 (58.4)

4 (17.4)

  

 Positive

32 (41.6)

19 (82.6)

  

Parenchyma atrophy (%)

  

1.502

0.220

 Negative

51 (66.2)

12 (52.2)

  

 Positive

26 (33.8)

11 (47.8)

  

Pancreatic duct expansion (%)

  

0.034

0.854

 Negative

25 (32.5)

7 (30.4)

  

 Positive

52 (67.5)

16 (69.6)

  

Vessels invasion (%)

  

0.088

0.766

 Negative

56 (72.7)

16 (69.6)

  

 Positive

21 (27.3)

7 (30.4)

  

Extrapancreatic perineural invasion status (%)

  

0.008

0.928

 Negative

51 (66.2)

15 (65.2)

  

 Positive

26 (33.8)

8 (34.8)

  

NIC of AP

0.09 (0.07, 0.12)

0.06 (0.04, 0.08)

 − 3.051

0.002

NZeff of AP

0.66 (0.64, 0.67)

0.64 (0.61, 0.65)

 − 1.994

0.046

λHU of AP

1.09 (0.78, 1.42)

0.77 (0.58, 1.03)

 − 3.94

 < 0.001

NIC of PVP

0.33 (0.30, 0.39)

0.24 (0.22, 0.29)

 − 4.902

 < 0.001

NZeff of PVP

0.86 (0.84, 0.87)

0.83 (0.80, 0.84)

 − 4.149

 < 0.001

λHU of PVP

2.48 ± 0.66

1.69 ± 0.44

3.354

 < 0.001

ECVf (%*)

34.70 (31.72, 37.87)

26.15 (20.97, 31.02)

 − 5.197

 < 0.001

  1. The % value reflects the composition ratio
  2. The %* value reflects the percentages
  3. F/Z/χ2 values represent the statistics of two independent sample t-tests for normal distribution, two independent sample t-tests for non-normal distribution and chi-square test, respectively
  4. AP arterial phase, DECT dual-energy computed tomography, ECVf the extracellular volume fraction, LN lymph node, NIC normalized iodine concentration, NZeff normalized effective atomic number, PVP portal venous phase, λHU slope of the spectral Hounsfield unit curve