Table 2 Uni- and multivariate Cox regression model for risk factors associated with late HCC recurrence
Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|
Variables | HR (95%CI) | p value | HR (95%CI) | p value |
Age (year) | 1.00 (0.99–1.02) | 0.641 | … | … |
Sex (male vs. female) | 1.82 (0.83–4.01) | 0.132 | … | … |
MELD score | 1.23 (1.05–1.45) | 0.010 | … | … |
FIB-4 index | 1.14 (1.08–1.20) | < 0.001 | … | … |
aMAP score | 1.06 (1.02–1.11) | 0.005 | … | … |
APRI score | 1.51 (1.29–1.78) | < 0.001 | 1.38 (1.13–1.68) | 0.001 |
Total bilirubin (µmol/L) | 1.04 (1.01–1.07) | 0.011 | … | … |
Aspartate transaminase (U/L) | 1.01 (1.00–1.01) | 0.002 | … | … |
Prothrombin time (s) | 1.39 (1.15–1.68) | < 0.001 | … | … |
Platelet count (× 109/L) | 0.99 (0.99–0.99) | 0.007 | … | … |
Esophageal varices (yes vs. no) | 1.87 (1.18–2.98) | 0.008 | … | … |
Splenomegaly (yes vs. no) | 1.99 (1.26–3.21) | 0.003 | … | … |
Maximum tumor size (cm) | 0.97 (0.88–1.07) | 0.594 | … | … |
Tumor number | ||||
2–3 vs. 1 | 1.95 (1.07–3.53) | 0.028 | 2.05 (1.15–3.65) | 0.015 |
> 3 vs. 1 | 8.45 (2.59–27.5) | < 0.001 | 10.05 (2.37–42.58) | 0.002 |
Bilobar involvement | 2.43 (1.21–4.87) | 0.013 | … | … |
Satellite nodule (yes vs. no)a | 1.62 (0.59–4.44) | 0.345 | … | … |
MVI (yes vs. no)a | 1.12 (0.54–2.30) | 0.627 | … | … |
Tumor differentiation | ||||
Moderate vs. well | 1.22 (0.37–4.08) | 0.743 | … | … |
Poor vs. well | 1.58 (0.49–5.04) | 0.443 | … | … |
Spleen volume (cm3) | 2.02 (1.31–3.12) | 0.001 | 1.01 (1.00–1.01) | 0.008 |