Table 1 Demographics and baseline characteristics of the study population
Entire cohort (n = 301) | Without late recurrence (n = 217) | With late recurrence (n = 84) | p value | |
|---|---|---|---|---|
Demographics and clinical characteristics | ||||
Age (year) | 52.9 (10.6) | 52.9 (10.5) | 52.9 (10.9) | 0.989 |
Sex (Male) | 261 (86.7%) | 184 (84.8%) | 77 (91.7%) | 0.166 |
Etiology | 0.394 | |||
Hepatitis B | 285 (94.7%) | 207 (95.4%) | 78 (92.9%) | |
Hepatitis C | 11 (3.6%) | 6 (2.8%) | 5 (5.9%) | |
Alcohol-related | 5 (1.7%) | 4 (1.8%) | 1 (1.2%) | |
Child–Pugh score | 5.1 (0.5) | 5.1 (0.3) | 5.2 (0.4) | 0.316 |
MELD score | 7.5 (1.3) | 7.4 (1.2) | 7.8 (1.4) | 0.010 |
ALBI score | − 2.89 (0.39) | − 2.92 (0.37) | − 2.83 (0.44) | 0.090 |
FIB-4 index | 3.39 (2.59) | 3.02 (2.09) | 4.33 (3.41) | 0.001 |
aMAP score | 59.1 (6.33) | 58.5 (6.11) | 60.6 (6.66) | 0.013 |
APRI score | 1.04 (0.90) | 0.91 (0.79) | 1.37 (1.09) | 0.001 |
BCLC stage | 0.095 | |||
0 | 61 (20.3%) | 45 (20.7%) | 16 (19.0%) | |
A | 214 (71.1%) | 158 (72.8%) | 56 (66.7%) | |
B | 26 (8.6%) | 14 (6.5%) | 12 (14.3%) | |
Laboratory parameters | ||||
AFP > 400 (ng/mL) | 63 (21.1%) | 43 (20.0%) | 20 (23.8%) | 0.570 |
Total bilirubin (mg/dL) | 15.1 (6.6) | 14.5 (6.4) | 16.8 (6.8) | 0.010 |
ALT (U/L) | 47.4 (52.4) | 43.6 (44.7) | 57.2 (67.7) | 0.092 |
AST (U/L) | 41.5 (38.1) | 38.5 (34.9) | 49.5 (44.8) | 0.044 |
Albumin (g/L) | 42.9 (4.4) | 43.1 (4.1) | 42.5 (5.1) | 0.344 |
Creatinine (mg/dL) | 73.1 (13.3) | 72.7 (13.4) | 74.1 (13.2) | 0.435 |
Prothrombin time (s) | 12.1 (0.97) | 12.0 (0.87) | 12.5 (1.12) | 0.001 |
Platelet count (× 109/L) | 123 (58.2) | 128 (56.6) | 109 (60.4) | 0.012 |
Radiological findings | ||||
Ascites (yes) | 19 (6.3%) | 12 (5.5%) | 7 (8.3%) | 0.527 |
Esophageal varices (yes) | 168 (55.8%) | 110 (50.7%) | 58 (69.0%) | 0.006 |
Splenomegaly (yes) | 175 (58.1%) | 117 (53.9%) | 58 (69.0%) | 0.024 |
Tumor number | 0.020 | |||
1 | 268 (89.0%) | 200 (92.2%) | 68 (81.0%) | |
2–3 | 27 (9.0%) | 14 (6.4%) | 13 (15.5%) | |
> 3 | 6 (2.0%) | 3 (1.4%) | 3 (3.5%) | |
Tumor size (cm) | 3.78 (2.54) | 3.82 (2.60) | 3.68 (2.40) | 0.661 |
Pathological parameters | ||||
Tumor differentiation | 0.810 | |||
High | 84 (28.2%) | 61 (28.5%) | 23 (27.4%) | |
Medium | 199 (66.8%) | 141 (65.9%) | 58 (69.0%) | |
Low | 15 (5.0%) | 12 (5.6%) | 3 (3.6%) | |
Volumetric indices | ||||
Total liver volume (cm3) | 1244 (296) | 1253 (307) | 1219 (266) | 0.331 |
Left lobe volume (cm3) | 422 (156) | 431 (158) | 400 (148) | 0.112 |
Right lobe volume (cm3) | 821 (242) | 823 (254) | 819 (211) | 0.892 |
Caudate volume (cm3) | 23 (15) | 23 (16) | 21 (11) | 0.139 |
Spleen volume (cm3) | 316 (157) | 294 (134) | 373 (194) | 0.001 |