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Insights into Imaging

Table 2 Numbera and proportion of 19 screening examinations prior to interval cancer and 91 screening examinations resulting in consecutive round screen-detected cancer, scored 2, 3, and 4 or 5 by one or more, two or more, and three or more of the five radiologists for digital breast tomosynthesis (DBT) + synthetic 2D images (SM), DBT alone, and SM alone in the blinded individual review

From: Digital breast tomosynthesis in mammographic screening: false negative cancer cases in the To-Be 1 trial

Screening examinations prior to interval cancer (n = 19)

DBT + SM

DBT

SM

 Proportion assigned in a review

n

% (fraction)

n

% (fraction)

n

% (fraction)

 Score 2 by 1 or more radiologists

3

15.8 (3/19)

2

10.5 (2/19)

2

10.5 (2/19)

 Score 3 by 1 or more radiologists

4

21.5 (4/19)

3

15.8 (3/19)

4

21.5 (4/19)

 Score 4 or 5 by 1 or more radiologists

2

10.5 (2/19)

2

10.5 (2/19)

0

0

 Score 2 by 2 or more radiologists

1

5.3 (1/19)

0

0

1

5.3 (1/19)

 Score 3 by 2 or more radiologists

2

10.5 (2/19)

1

5.3 (1/19)

1

5.3 (1/19)

 Score 4 or 5 by 2 or more radiologists

1

5.3 (1/19)

1

5.3 (1/19)

0

0

 Score 2 by 3 or more radiologists

0

0

0

0

0

0

 Score 3 by 3 or more radiologists

1

5.3 (1/19)

1

5.3 (1/19)

0

0

 Score 4 or 5 by 3 or more radiologists

0

0

0

0

0

0

Screening examinations resulting in consecutive round screen-detected cancer (n = 91)

DBT + SM

DBT

SM

 Proportion assigned in a review

n

% (fraction)

n

% (fraction)

n

% (fraction)

 Score 2 by 1 or more radiologists

43

47.3 (43/91)

35

38.5 (35/91)

34

37.4 (34/91)

 Score 3 by 1 or more radiologists

41

45.1 (41/91)

34

37.4 (34/91)

23

25.3 (23/91)

 Score 4 or 5 by 1 or more radiologists

33

36.3 (33/91)

28

30.8 (28/91)

8

8.8* (8/91)

 Score 2 by 2 or more radiologists

22

24.2 (22/91)

12

13.2 (12/91)

12

13.2 (12/91)

 Score 3 by 2 or more radiologists

18

19.9 (18/91)

15

16.5 (15/91)

5

5.5** (5/91)

 Score 4 or 5 by 2 or more radiologists

6

6.6 (6/91)

6

6.6 (6/91)

1

1.1 (1/91)

 Score 2 by 3 or more radiologists

7

7.7 (7/91)

3

3.3 (3/91)

4

4.4 (4/91)

 Score 3 by 3 or more radiologists

7

7.7 (7/91)

4

4.4 (4/91)

3

3.3 (3/91)

 Score 4 or 5 by 3 or more radiologists

3

3.3 (3/91)

3

3.3 (3/91)

0

0

  1. Score 2 probably benign, 3 intermediate suspicion of malignancy, 4 probably malignant, and 5 high suspicion of malignancy
  2. *p < 0.001 for comparison of DBT and SM
  3. **p = 0.02 for comparison of DBT and SM
  4. aNumber shows the number of cases chosen/assigned for each radiologist and different combinations of radiologists, some of these cases are the same, but the cases could also differ for the different radiologists
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