Fig. 4
From: MRI characteristics of chemotherapy-related central neurotoxicity: a pictorial review
Diagrammatic illustration of MRI diffusion-weighted imaging (DWI) changes in Methotrexate (MTX) and 5-FU/capecitabine central neurotoxicity. a In MTX-related neurotoxicity, DWI changes typically involve the centrum semiovale (arrows) and corona radiata (arrowhead) and may be unilateral, bilateral, symmetrical, or asymmetrical in location. Rarely, reversible splenial lesion (RSL) may occur (star). b In 5-FU and capecitabine neurotoxicity, DWI changes involve the corona radiata (arrows), deep white matter, corticospinal tracts (curved arrows), middle cerebellar peduncles (arrow heads), and the splenium of the corpus callosum (RSL) (stars). Rarely, lesions may involve bilateral basal ganglia and thalami