Fig. 2

Capecitabine-induced leukoencephalopathy. An elderly patient on capecitabine for colon adenocarcinoma presented with transient expressive dysphasia and unsteady gait. Axial diffusion-weighted imaging (DWI) (a, c) and axial apparent diffusion coefficient (ADC) (b, d) MRI demonstrates restricted diffusion in the corona radiata (arrows in a, b) and splenium of the corpus callosum (arrows in c and d). These findings are compatible with capecitabine-induced leukoencephalopathy. A follow-up MRI after cessation of capecitabine administration showed near-complete resolution of the diffusion changes in bilateral corona radiata (arrows in e) and splenium of the corpus callosum (arrows in g and h) on the axial DWI (e, g) and ADC (f, h) images