Table 3 CMR parameters in WD patients and controls
Parameters | Controls (n = 40) | WD (n = 41) | p | WD-neuro − (n = 17) | WD-neuro + (n = 24) | p |
|---|---|---|---|---|---|---|
Cardiac morphology and function | ||||||
LVEF (%) | 60.5 ± 6.0 | 59.2 ± 5.9 | 0.652 | 60.5 ± 6.5 | 58.3 ± 5.4 | 0.703 |
LVCI (L/min/m2) | 3.1 ± 0.6 | 3.1 ± 0.8 | 0.976 | 3.3 ± 1.0 | 3.0 ± 0.7 | 0.703 |
LVEDVi (mL/m2) | 74.0 ± 10.2 | 77.4 ± 11.2 | 0.477 | 75.8 ± 11.7 | 78.4 ± 10.9 | 0.703 |
LVESVi (mL/m2) | 29.2 ± 6 | 32.2 ± 6.3 | 0.204 | 31.1 ± 7.1 | 32.9 ± 5.8 | 0.703 |
LVSVi (mL/m2) | 45.2 ± 7.8 | 45.2 ± 9.2 | 0.978 | 44.8 ± 10.9 | 45.5 ± 8.0 | 0.795 |
LV mass index (g/m2) | 42.0 ± 6.9 | 42.9 ± 6.9 | 0.786 | 42.2 ± 6.3 | 43.5 ± 7.3 | 0.703 |
RVEF (%) | 61.5 ± 7.7 | 59.0 ± 9.3 | 0.654 | 61.2 ± 8.9 | 57.4 ± 9.4 | 0.552 |
RVCI (L/min/m2) | 3.2 ± 0.7 | 3.2 ± 0.9 | 0.937 | 3.3 ± 0.9 | 3.1 ± 1.0 | 0.664 |
RVEDVi (mL/m2) | 76 ± 14.8 | 78.6 ± 13.5 | 0.654 | 74.9 ± 13.7 | 81.3 ± 13.0 | 0.552 |
RVESVi (mL/m2) | 29.5 ± 8.9 | 32.3 ± 9.1 | 0.654 | 29.1 ± 8.3 | 34.6 ± 9.2 | 0.440 |
RVSVi (mL/m2) | 46.5 ± 9.7 | 46.3 ± 10.5 | 0.937 | 45.9 ± 10.9 | 46.6 ± 10.4 | 0.931 |
LAEF (%) | 59.5 ± 6.7 | 59.1 ± 6.5 | 0.937 | 58.0 ± 6.2 | 59.8 ± 6.7 | 0.664 |
LAVi max (mL/m2) | 33.6 ± 6.7 | 35.6 ± 10.1 | 0.654 | 35.6 ± 11.4 | 35.6 ± 9.3 | > 0.99 |
LAVi min (mL/m2) | 13.7 ± 4.0 | 14.5 ± 4.7 | 0.654 | 15.2 ± 5.9 | 14.1 ± 3.6 | 0.679 |
2D LV-Strain | ||||||
GRS (%) | 34.0 ± 4.7 | 32.6 ± 4.9 | 0.226 | 33.5 ± 5.2 | 31.9 ± 4.7 | 0.672 |
GCS (%) | -19.4 ± 1.6 | -18.9 ± 1.7 | 0.226 | -19.1 ± 1.9 | -18.7 ± 1.6 | 0.715 |
GLS (%) | -18.1 ± 2.1 | -17.4 ± 2.5 | 0.226 | -18.1 ± 3.0 | -17.0 ± 2.1 | 0.600 |
Tissue characterization | ||||||
Global native T1 (ms) | 1046.5 ± 33.1 | 1085.1 ± 39.1 | < 0.001 | 1082.8 ± 37.8 | 1086.7 ± 40.7 | 0.795 |
Prolonged T1, % | 5.1 | 42.1 | < 0.001 | 47.1 | 38.5 | 0.703 |
Global T2 (ms) | 51.5 ± 2.6 | 54.2 ± 3.3 | < 0.001 | 53.8 ± 3.1 | 54.5 ± 3.6 | 0.703 |
Prolonged T2, % | 12.5 | 28.5 | 0.006 | 25.0 | 31.0 | 0.345 |
Global ECV (%) | 24.3 ± 3.7 | 31.8 ± 3.6 | < 0.001 | 30.3 ± 2.5 | 32.9 ± 3.8 | 0.042 |
Prolonged ECV, % | 4.0 | 66.5 | < 0.001 | 57.8 | 72.6 | 0.042 |
LGE performed | ||||||
Non-ischemic LGE present, n (%) | 0 (0%) | 32 (78%) | 0.004 | 15 (88%) | 17 (71%) | 0.672 |
RVIP, n (%) | 0 (0%) | 15 (37%) | 0.004 | 4 (24%) | 11 (46%) | 0.600 |
Interventricular septum, n (%) | 0 (0%) | 9 (22%) | 0.005 | 3 (18%) | 6 (25%) | > 0.99 |
Inferior, n (%) | 0 (0%) | 3 (8%) | 0.241 | 1 (4%) | 2 (8%) | > 0.99 |
Inferolateral, n (%) | 0 (0%) | 5 (12%) | 0.110 | 2 (12%) | 3 (13%) | > 0.99 |