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Table 3 The CECT features of included lesions

From: Comparison contrast-enhanced CT with contrast-enhanced US in diagnosing combined hepatocellular-cholangiocarcinoma: a propensity score-matched study

Imaging features

cHCC-CCAa

(n = 45)

HCC

(n = 90)

p value#

CT scan

 Size (cm)

5.5 ± 3.6

5.3 ± 3.4

0.719

 Number of tumors (single)

33 (73.3)

82 (80.0)

0.511

 Cirrhosis

20 (44.4)

62 (68.9)

0.009

CECT

LI-RADS major features

 Nonrim APHE volume (< 50%)

26 (57.8)

11 (12.2)

< 0.001

 Rim APHE

17 (37.8)

5 (5.6)

< 0.001

 Nonperipheral washout volume (< 50%)

22 (48.9)

18 (20.0)

< 0.001

 Peripheral washout

22 (48.9)

8 (8.9)

< 0.001

 Enhancing capsule

28 (62.2)

52 (57.8)

0.621

 Tumor in vein

1 (2.2)

8 (9.0)

0.169

LI-RADS category

  

< 0.001

 LR-3

1 (2.2)

2 (2.2)

 

 LR-4

8 (17.8)

8 (8.9)

 

 LR-5

12 (26.7)

61 (67.8)

 

 LR-M

23 (51.1)

11(12.2)

 

 LR-TIV

1 (2.2)

8 (8.9)

 

LI-RADS ancillary features

 Corona enhancement

11 (24.4)

21 (23.3)

0.889

 Nonenhancing capsule

4 (8.9)

17 (18.9)

0.132

 Nodule-in-nodule architecture

9 (20.0)

23 (25.6)

0.526

 Mosaic architecture

11 (24.4)

30 (33.3)

0.326

 Blood products in mass

2 (4.4)

5 (5.6)

1.000

 Fat in mass, more than adjacent liver

0 (0.0)

1 (1.1)

1.000

 Delayed central enhancement

2 (4.4)

7 (7.8)

0.464

 Internal artery

14 (31.1)

35 (38.9)

0.449

 Necrosis or severe ischemia

18 (40.0)

48 (53.3)

0.201

 Infiltrative appearance

20 (44.4)

38 (42.2)

0.855

Other features

 Tumor capsule integrity (incomplete)

27 (60.0)

36 (40.0)

0.044

 Tumor margin (smooth)

  

0.855

 Tumor growth subtype

  

< 0.001

  Type 1: single nodular type

23 (51.1)

62 (68.9)

 

  Type 2: single nodule with extranodular growth

12 (26.7)

26 (28.9)

 

  Type 3: multiple confluent nodules

10 (22.2)

2 (2.2)

 

 Lesion with LR-M featuresb

24 (53.3)

11 (12.2)

< 0.001

  1. cHCC-CCA combined hepatocellular-cholangiocarcinoma, HCC hepatocellular carcinoma, CECT contrast-enhanced computed tomography, APHE arterial phase hyperenhancement, LI-RADS liver imaging reporting and data system, LR liver imaging reporting and data system category
  2. #Categorical variables were compared by the χ2 test or Fisher’s exact test
  3. aUnless otherwise indicated, data are number of patients, with percentage in parentheses
  4. bLesion with LR-M features means that lesions have LR-M category features with or without tumor thrombus in a vessel on CECT