Table 2 The CEUS features of included lesions
Imaging features | cHCC-CCAa (n = 45) | HCC (n = 90) | p value# |
|---|---|---|---|
B-model ultrasound | |||
Size (cm) | 5.6 ± 3.5 | 5.8 ± 3.8 | 0.799 |
Number of tumors (single) | 18 (40.0) | 26 (28.9) | 0.243 |
Cirrhosis | 23 (51.1) | 43 (47.8) | Â |
Nodule echo (hypo-) | 40 (88.9) | 68 (75.6) | 0.109 |
Boundary (well) | 13 (28.9) | 35 (38.9) | 0.170 |
Shape (regular) | 16 (35.6) | 45 (50.0) | 0.143 |
CEUS | |||
Enhancement level in the AP | Â | Â | 1.000 |
 Hyperenhancement | 44 (97.8) | 89 (98.9) |  |
 Isoenhancement | 1 (2.2) | 1 (1.1) |  |
 Hypoenhancement | 0 (0.0) | 0 (0.0) |  |
Enhancement level in the PVP | Â | Â | 0.002 |
 Hyperenhancement | 0 (0.0) | 0 (0.0) |  |
 Isoenhancement | 5 (11.1) | 32 (35.6) |  |
 Hypoenhancement | 40 (88.9) | 58 (64.4) |  |
Enhancement level in the LP | Â | Â | 0.424 |
 Hyperenhancement | 0 (0.0) | 0 (0.0) |  |
 Isoenhancement | 1 (2.2) | 6 (6.7) |  |
 Hypoenhancement | 44 (97.8) | 84 (93.3) |  |
LI-RADS major features | |||
 Rim APHE | 1 (2.3) | 1 (1.1) | 1.000 |
 Early washout | 19 (42.4) | 23 (25.6) | 0.075 |
 Marked washout within two minutes | 0 (0.0) | 1 (1.1) | 1.000 |
 Mild and late washout | 44 (97.8) | 84 (93.3) | 1.000 |
 Tumor in vein | 7 (15.6) | 13 (14.4) | 1.000 |
LI-RADS category | Â | Â | 0.113 |
 LR-4 | 1 (2.2) | 6 (6.7) |  |
 LR-5 | 20 (44.4) | 53 (58.9) |  |
 LR-M | 17 (37.8) | 18 (20) |  |
 LR-TIV | 7 (15.6) | 13 (14.4) |  |
LI-RADS ancillary features | |||
 Nodule-in-nodule architecture | 0 (0.0) | 0 (0.0) | NA |
 Mosaic architecture | 9 (20.0) | 14 (15.6) | 0.628 |
Other features | |||
 Tumor supply artery | 24 (53.3) | 44 (48.9) | 0.716 |
 Circumscribed enhancement (well) | 20 (44.4) | 45 (50.0) | 0.587 |
 Unclear boundary in the intratumoral nonenhanced area | 32 (71.1) | 34 (37.8) | < 0.001 |
 Intratumoral vein in LP | 12 (26.7) | 17 (18.9) | 0.206 |
 The proportion of washout (partial) | 32 (71.1) | 36 (40.0) | < 0.001 |
 Necrosis or severe ischemia | 4 (8.9) | 17 (18.9) | 0.207 |