Skip to main content
Insights into Imaging

Table 1 Demographic and clinical characteristics of IAC patients with or without the presence of MP/S components

From: Imaging phenotyping using 18F-FDG PET/CT radiomics to predict micropapillary and solid pattern in lung adenocarcinoma

Clinical features

Training cohort (n = 500)

Test cohort 1 (n = 176)

Test cohort 2 (n = 170)

MP/S < 5%

MP/S ≥ 5%

p value

MP/S < 5%

MP/S ≥ 5%

p value

MP/S < 5%

MP/S ≥ 5%

p value

Gender

  

 < 0.001

  

 < 0.001

  

0.158

 Male

76 (34.2%)

178 (64.0%)

 

24 (33.8%)

70 (66.7%)

 

31 (45.6%)

59 (57.8%)

 

 Female

146 (65.8%)

100 (36.0%)

 

47 (66.2%)

35 (33.3%)

 

37 (54.4%)

43 (42.2%)

 

Age (years)

59.1 (8.70)

59.6 (9.50)

0.526

62.2 (9.08)

58.8 (9.64)

0.018

62.5 (9.52)

61.1 (9.33)

0.348

Smoking

  

 < 0.001

  

 < 0.001

  

0.034

 Current or ever

67 (30.2%)

142 (51.1%)

 

18 (25.4%)

56 (53.3%)

 

22 (32.4%)

51 (50.0%)

 

 Never

155 (69.8%)

136 (48.9%)

 

53 (74.6%)

49 (46.7%)

 

46 (67.6%)

51 (50.0%)

 

T stage

  

 < 0.001

  

 < 0.001

  

 < 0.001

 T1

163 (73.4%)

121 (43.5%)

 

52 (73.2%)

39 (37.1%)

 

49 (72.1%)

32 (31.4%)

 

 T2

53 (23.9%)

115 (41.4%)

 

17 (23.9%)

53 (50.5%)

 

15 (22.1%)

47 (46.1%)

 

 T3

4 (1.80%)

24 (8.63%)

 

1 (1.41%)

10 (9.52%)

 

4 (5.88%)

15 (14.7%)

 

 T4

2 (0.90%)

18 (6.47%)

 

1 (1.41%)

3 (2.86%)

 

0 (0.00%)

8 (7.84%)

 

N stage

  

 < 0.001

  

 < 0.001

  

 < 0.001

 N0

200 (90.1%)

154 (55.4%)

 

65 (91.5%)

63 (60.0%)

 

60 (88.2%)

56 (54.9%)

 

 N1

10 (4.50%)

47 (16.9%)

 

3 (4.23%)

13 (12.4%)

 

4 (5.88%)

14 (13.7%)

 

 N2

10 (4.50%)

72 (25.9%)

 

3 (4.23%)

27 (25.7%)

 

3 (4.41%)

31 (30.4%)

 

 N3

2 (0.90%)

5 (1.80%)

 

0 (0.00%)

2 (1.90%)

 

1 (1.47%)

1 (0.98%)

 

Nodule type

  

 < 0.001

  

 < 0.001

  

 < 0.001

 pGGN

20 (9.01%)

1 (0.36%)

 

9 (12.7%)

0 (0.00%)

 

7 (10.3%)

1 (0.98%)

 

 mGGN

78 (35.1%)

13 (4.68%)

 

21 (29.6%)

2 (1.90%)

 

22 (32.4%)

4 (3.92%)

 

 Solid

124 (55.9%)

264 (95.0%)

 

41 (57.7%)

103 (98.1%)

 

39 (57.4%)

97 (95.1%)

 

Air bronchogram

  

0.587

  

0.322

  

0.421

 ( +)

55 (24.8%)

62 (22.3%)

 

24 (33.8%)

27 (25.7%)

 

17 (25.0%)

19 (18.6%)

 

 ( −)

167 (75.2%)

216 (77.7%)

 

47 (66.2%)

78 (74.3%)

 

51 (75.0%)

83 (81.4%)

 

Vacuole sign

  

0.707

  

0.806

  

0.325

 ( +)

30 (13.5%)

42 (15.1%)

 

11 (15.5%)

19 (18.1%)

 

8 (11.8%)

19 (18.6%)

 

 ( −)

192 (86.5%)

236 (84.9%)

 

60 (84.5%)

86 (81.9%)

 

60 (88.2%)

83 (81.4%)

 

Pleural adhesion

  

0.014

  

0.423

  

0.276

 ( +)

129 (58.1%)

192 (69.1%)

 

43 (60.6%)

71 (67.6%)

 

41 (60.3%)

71 (69.6%)

 

 ( −)

93 (41.9%)

86 (30.9%)

 

28 (39.4%)

34 (32.4%)

 

27 (39.7%)

31 (30.4%)

 

Shape

  

0.079

  

0.027

  

1

 Regular

47 (21.2%)

41 (14.7%)

 

18 (25.4%)

12 (11.4%)

 

19 (27.9%)

28 (27.5%)

 

 Irregular

175 (78.8%)

237 (85.3%)

 

53 (74.6%)

93 (88.6%)

 

49 (72.1%)

74 (72.5%)

 

 Maximum length

2.00 [1.50; 2.60]

2.80 [2.10; 3.80]

 < 0.001

2.00 [1.60; 2.55]

2.80 [2.20; 3.60]

 < 0.001

2.05 [1.60; 2.70]

3.00 [2.30; 4.10]

 < 0.001

Interface

  

0.001

  

0.327

  

0.096

 Clear

75 (33.8%)

136 (48.9%)

 

27 (38.0%)

49 (46.7%)

 

25 (36.8%)

52 (51.0%)

 

 Unclear

147 (66.2%)

142 (51.1%)

 

44 (62.0%)

56 (53.3%)

 

43 (63.2%)

50 (49.0%)

 

SUVmax

2.56 [1.23; 5.69]

9.39 [5.85; 14.3]

 < 0.001

3.35 [1.65; 6.73]

9.30 [5.45; 15.3]

 < 0.001

3.06 [1.30; 5.36]

10.2 [5.94; 14.0]

 < 0.001

SUVavg

1.48 [0.76; 3.30]

5.48 [3.42; 8.55]

 < 0.001

2.00 [0.98; 4.08]

5.55 [3.24; 8.39]

 < 0.001

1.81 [0.87; 3.31]

6.20 [3.68; 8.38]

 < 0.001

MTV

1.67 [1.07; 3.48]

4.61 [2.12; 10.8]

 < 0.001

1.82 [1.17; 3.22]

4.33 [2.05; 8.85]

 < 0.001

2.09 [0.89; 3.57]

4.63 [2.42; 14.4]

 < 0.001

  1. Medians (interquartile range) on behalf of maximum length, SUVmax, SUVavg, and MTV, because they did not comply with normal distribution
  2. p < 0.05 showed significant difference
Back to article page