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Table 4 Univariate and multivariate analyses of risk factors for Ki-67 level in the training cohort

From: Correlation analysis of MR elastography and Ki-67 expression in intrahepatic cholangiocarcinoma

Variables

Univariate analysis

Multivariate analysis

Odds ratio

p

Odds ratio

p

Sex

3.844 (1.632–9.053)

0.002*

CA19-9

2.775 (1.205–6.391)

0.016*

Largest diameter

0.948 (0.798–1.126)

0.540

Tumor margin

1.348 (0.556–3.270)

0.509

Signal homogeneity

1.024 (0.402–2.610)

0.961

Arterial enhancement

Globala

Partial

2.667 (0.237–30.066)

0.427

Peripheral enhancement

7.407 (0.788–69.632)

0.08

Enhancement pattern

Progressivea

Persistent

1.941 (0.194–19.461)

0.573

Degressive-washout

0.324 (0.076–1.384)

0.128

APHE

1.250 (0.480–3.258)

0.648

Capsule

2.500 (0.826–7.564)

0.105

Targetoid appearance

3.846 (1.382–10.705)

0.010*

Satellite nodules

1.234 (0.513–2.970)

0.639

Bile duct dilation

1.405 (0.602–3.278)

0.432

Liver capsule retraction

1.048 (0.455–2.410)

0.913

Hemorrhage in mass

1.447 (0.195–10.728)

0.718

Necrotic or cystic portion

1.167 (0.504–2.705)

0.718

Central scar

1.145 (0.510–2.571)

0.743

Central darkness on T2WI

1.100 (0.489–2.476)

0.818

Vessel invasion

1.394 (0.527–3.685)

0.503

Lymphadenectasis

1.337 (0.592–3.023)

0.485

Tumor ADC

0.028 (0.004–0.208)

 < 0.001*

0.030 (0.002–0.476)

0.013

Tumor stiffness

1.640 (1.327–2.027)

 < 0.001*

1.669 (1.307–2.131)

 < 0.001*

Liver stiffness

0.950 (0.694–1.299)

0.747

  1. CEA carcinoembryonic antigen, CA19-9 cancer antigen 19–9, APHE arterial peritumoral hyperenhancement, T2WI T2-weighted imaging, ADC apparent diffusion coefficient, OR odds ratio, 95% CI 95% confidence interval
  2. … indicate variables not included in the equation of the multivariate logistic stepwise regression model
  3. aData were used as the reference category
  4. *p < 0.05