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Table 3 MR imaging characteristics of tumors

From: Correlation analysis of MR elastography and Ki-67 expression in intrahepatic cholangiocarcinoma

Variable

 

High Ki-67 (n = 57)

Low Ki-67 (n = 40)

p

Largest diameter (cm)a

5.74 ± 2.37

5.61 ± 2.16

5.91 ± 2.65

0.544

Location left/right/left + right/caudal lobe

43 (44.3%)/45 (46.4%)/7 (7.2%)/2 (2.1%)

26 (45.5%)/27 (47.4%)/3 (5.3%)/1 (1.8%)

17 (42.5%)/18 (45%)/4 (10.0%)/1 (2.5%)

0.830

Tumor margin

Well-defined/ill-defined

69 (71.1%)/28 (28.9%)

42 (73.7%)/15 (26.3%)

27 (67.5%)/13 (32.5%)

0.508

Signal homogeneity

Homogeneous/heterogeneous

24 (24.7%)/73 (75.3%)

14 (24.6%)/43 (75.4%)

10 (25.0%)/30 (75.0%)

0.961

Arterial enhancement

Global/partial/peripheral enhancement

5 (5.2%)/15 (15.5%)/77 (79.4%)

1 (1.8%)/6 (10.5%)/50 (87.7%)

4 (10.0%)/9 (22.5%)/27 (67.5%)

0.036*

Enhancement pattern

Progressive/persistent/degressive-washout

84 (86.6%)/4 (4.1%)/9 (9.3%)

51 (89.5%)/3 (5.3%)/3 (5.3%)

33 (82.5%)/1 (2.5%)/6 (15.0%)

0.295

APHE Y/N

75 (77.3%)/22 (22.7%)

45 (78.9%)/12 (21.1%)

30 (75.0%)/10 (25.0%)

0.648

Capsule Y/N

20 (20.6%)/77 (79.4%)

15 (26.3%)/42 (73.7%)

5 (12.5%)/35 (87.5%)

0.098

Targetoid appearance Y/N

76 (78.4%)/21 (21.6%)

50 (87.7%)/7 (12.3%)

26 (65.0%)/14 (35.0%)

0.007*

Satellite nodules Y/N

29 (29.9%)/68 (70.1%)

16(28.1%)/41 (71.9%)

13 (32.5%)/27 (67.5%)

0.639

Bile duct dilation Y/N

61 (62.9%)/36 (37.1%)

34 (59.6%)/23 (40.4%)

27 (67.5%)/13 (32.5%)

0.431

Liver capsule retraction Y/N

37 (38.1%)/60 (61.9%)

22 (38.6%)/35 (61.4%)

15 (37.5%)/25 (62.5%)

0.913

Hemorrhage in mass Y/N

4 (4.1%)/93 (95.9%)

2 (3.5%)/55 (96.5%)

2(5.0%)/38 (95.0%)

1.000

Necrotic or cystic portion Y/N

36 (37.1%)/61 (62.9%)

22 (38.6%)/35 (61.4%)

14 (35.0%)/26 (65.0%)

0.718

Central scar Y/N

48 (49.5%)/49 (50.5%)

29 (50.9%)/28 (49.1%)

19 (47.5%)/21 (52.5%)

0.743

Central darkness on T2WI Y/N

45 (46.4%)/52 (53.6%)

27(47.4%)/30 (52.6%)

18 (45.0%)/22 (55.0%)

0.818

Vessel invasion Y/N

76 (78.4%)/21 (21.6%)

46 (80.7%)/11 (19.3%)

30 (75.0%)10/ (25.0%)

0.502

Lymphadenectasis Y/N

42 (43.3%)/55 (56.7%)

23 (40.4%)/34 (59.6%)

19 (47.5%)/21 (52.5%)

0.484

Distant metastasis Y/N

11 (11.3%)/86 (88.7%)

8 (14.0%)/49 (86.0%)

3 (7.5%)/37 (92.5%)

0.517

Tumor ADC (× 103 mm2/s)b

1.13 (0.96, 1.30)

1.02 (0.87, 1.22)

1.19 (1.06, 1.42)

 < 0.001*

Tumor stiffness (kPa)b

7.94 (6.23, 11.09)

10.16 (7.17, 12.04)

6.37 (5.65, 7.69)

 < 0.001*

Liver stiffness (kPa)b

2.74 (2.30, 3.52)

2.65 (2.30, 3.64)

2.77 (2.31, 3.47)

0.959

  1. Unless otherwise specified, data are numbers of lesions
  2. Quantitative variables are analyzed using the independent t-test or Mann–Whitney U-test; categorical variables are analyzed using Pearson’s χ2 test or Fisher’s exact test, as appropriate
  3. APHE arterial peritumoral hyperenhancement, T2WI T2-weighted imaging, ADC apparent diffusion coefficient
  4. aData are mean ± standard deviation
  5. bData are median (Q1, Q3)
  6. * p < 0.05