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Table 1 Recommended procedure dependent on selected previous adverse reactions

From: Why mild contrast medium-induced reactions are sometimes over-treated and moderate/severe reactions of internal organs are undertreated: a summary based on RadioComics

History of…

Suggested prophylaxis

…mild reactions

 Heat/cold feeling

 Erythema, flush

 Itching

 Localized urticaria

 Nausea/vomiting

 Dizziness

• Application of a non-culprit CM

• Injection of low-dose CM (with reduced injection speed)

• (none)

…moderate or severe reactions

 Contrast-induced acute kidney injury  (CI-AKI)

• Prophylaxis (e.g., hydration) adapted to eGFR/serum-creatinine [9]

• Consideration of nephrotoxic drugs

• Consideration of several contrast-enhanced imaged guided examinations within a few days

 Generalized urticaria

 Angioedema

 Conjunctivitis, rhinitis

 Hypo-/hypertension

 Mild bronchial symptoms

 Anaphylaxis

Application of a non-culprit CM according to the results of an allergy skin testing