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Insights into Imaging
Fig. 2 | Insights into Imaging

Fig. 2

From: Preoperative prediction of cholangiocyte phenotype hepatocellular carcinoma on contrast-enhanced MRI and the prognostic implication after hepatectomy

Fig. 2

MRI features of cholangiocyte phenotype and classical hepatocellular carcinoma (HCC). A 54-year-old male patient with cholangiocyte phenotype HCC (a–f), and a 71-year-old male patient with classical HCC (g–l). T2WI showed hyperintense lesions (a, g), pre-contrast T1WI showed hypointense lesions (b, h), and “nodule in nodule architecture” was observed in the cholangiocyte phenotype HCC (a–d, yellow arrow). Arterial phase images showed “rim arterial phase hyperenhancement (APHE)” (c, orange arrow) and “non-rim APHE” (i, red arrow). Portal venous phase images showed “peripheral washout” with nodular delayed enhancement (d, yellow arrow) and “nonperipheral washout” (j, blue arrow) and smooth margin with enhanced capsule (j, white arrow); immunohistochemical staining revealed the CK7 (e, k, × 100) and CK19 (f, l, × 100) positive (e, f) and negative (k, l) expressions, respectively

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