Cardiovascular metrics on CT pulmonary angiography in patients with pulmonary hypertension — re-evaluation under the updated guidelines of pulmonary hypertension

Insights into Imaging

Table 3 ROCs of cardiovascular metrics and prediction model in diagnosis of PH under the updated and old diagnostic criteria

Cardiovascular metrics	Cut-off value	AUC of ROC	95% CI		p value	Sensitivity %	Specificity %	Youden Index
Cardiovascular metrics	Cut-off value	AUC of ROC	Lower limit	Upper limit	p value	Sensitivity %	Specificity %	Youden Index
CTPA metrics for mPAP > 20 mmHg
MPAd (mm)	30.0	0.906 ± 0.022	0.860	0.942	< .001*	83.1	90.4	0.735
RVFWT (mm)	3.8	0.874 ± 0.028	0.822	0.915	< .001*	89.1	71.0	0.601
MPAd/AAd ratio	1.1	0.836 ± 0.027	0.780	0.883	< .001*	57.1	95.2	0.522
Predicting model▲	-	0.938 ± 0.018	0.897	0.996	< .001*	-	-
CTPA metrics for mPAP ≥ 25 mmHg
MPAd (mm)	30.4	0.899 ± 0.022	0.851	0.936	< .001*	91.8	77.1	0.689
RVWT (mm)	4.8	0.783 ± 0.031	0.722	0.836	< .001*	64.8	81.3	0.460
MPAd/AAd ratio	1.0	0.850 ± 0.026	0.796	0.895	< .001*	77.1	76.0	0.531
Predicting model▼	-	0.919 ± 0.021	0.875	0.952	< .001*	-	-

PH Pulmonary hypertension, ROC Receiver operating characteristic curve, AUC Area under the curve, CTPA Computed tomography pulmonary angiography, MPAd the main pulmonary arterial diameter, MPAd/AAd ratio MPAd/ascending aorta diameter ratio, RVFWT right ventricular free wall thickness; predicting model binary logistic regression
▲ MPAd and RVWT; ▼ MPAd and MPAd/AAd ratio and RVWT; *p < 0.001