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Insights into Imaging

Table 2 Correlations between pathological characteristics and tissue stiffness

From: Stiffness on shear wave elastography as a potential microenvironment biomarker for predicting tumor recurrence in HBV-related hepatocellular carcinoma

Pathological characteristics

Intratumoral stiffness (kPa)

p

Peritumoral stiffness (kPa)

p

Adjacent liver stiffness (kPa)

p

Distant liver stiffness (kPa)

p

Tumor size

 

0.533

 

0.014

 

0.959

 

0.607

 ≤ 5 cm

33.9 (18.6–49.4)

 

40.7 (23.2–50.5)

 

11.3 (8.9–18.9)

 

8.8 (7.0–11.5)

 

 > 5 cm

33.6 (24.6–49.9)

 

53.3 (33.9–64.6)

 

11.8 (9.0–18.0)

 

9.3 (7.6–10.8)

 

Proportion of stroma

 

0.016

 

0.165

 

0.290

 

0.754

 ≤ 20%

30.9 (16.7–40.8)

 

43.3 (30.2–55.2)

 

12.9 (9.1–20.6)

 

9.2 (7.5–11.7)

 

 > 20%

35.4 (26.5–54.2)

 

51.7 (28.0–66.5)

 

11.1 (8.7–17.4)

 

9.1 (7.2–10.8)

 

Tumor necrosis

 

0.203

 

0.230

 

0.997

 

0.288

 Absent

27.9 (17.8–50.1)

 

44.9 (21.7–61.2)

 

12.5 (8.1–19.4)

 

9.1 (7.9–12.8)

 

 Present

34.9 (25.6–49.8)

 

48.8 (30.2–64.7)

 

11.7 (9.2–18.0)

 

9.2 (7.2–10.6)

 

Proportion of necrosis

 

0.158

 

0.205

 

0.454

 

0.828

 < 20%

32.9 (20.8–44.2)

 

44.7 (23.9–61.9)

 

12.0 (9.0–19.4)

 

8.5 (7.3–11.4)

 

 ≥ 20%

34.5 (26.0–55.1)

 

51.7 (30.1–68.2)

 

11.0 (8.9–17.5)

 

9.4 (7.0–11.0)

 

Edmondson-Steiner grade

 

0.376

 

0.104

 

0.833

 

0.577

 Grade I–II

30.7 (20.8–43.6)

 

44.3 (25.2–55.7)

 

12.1 (8.2–19.2)

 

9.1 (7.0–12.2)

 

 Grade III–IV

34.5 (23.1–52.1)

 

51.1 (30.3–67.6)

 

11.1 (9.2–17.7)

 

9.3 (7.4–10.6)

 

Tumor capsule

 

0.602

 

0.004

 

0.026

 

0.497

 Absent

35.3 (18.3–57.9)

 

30.4 (19.3–47.7)

 

9.5 (8.0–12.9)

 

8.7 (6.6–10.9)

 

 Present

32.9 (23.6–46.5)

 

50.2 (32.1–63.9)

 

12.3 (9.3–19.4)

 

9.3 (7.5–11.5)

 

Peritumoral lymphocytic reaction

 

0.542

 

0.353

 

0.605

 

0.541

 Low

31.3 (16.8–46.1)

 

43.8 (24.2–63.3)

 

11.9 (9.5–20.7)

 

8.5 (6.9–11.4)

 

 Moderate

32.4 (25.4–49.0)

 

50.6 (39.7–66.5)

 

11.9 (9.5–17.5)

 

9.3 (7.9–10.7)

 

 High

38.2 (22.4–54.0)

 

44.9 (25.3–61.0)

 

10.3 (8.1–18.7)

 

11.4 (6.6–19.4)

 

Microvascular invasion

 

0.015

 

0.021

 

0.121

 

0.219

 Absent

30.6 (18.3–43.2)

 

40.5 (23.6–61.9)

 

10.9 (8.6–17.5)

 

8.5 (7.2–10.5)

 

 Present

39.9 (30.4–53.4)

 

52.7 (40.3–63.9)

 

13.4 (9.3–10.9)

 

10.2 (7.9–11.8)

 

Cirrhosis of background liver

 

0.777

 

0.050

 

0.036

 

0.002

 Absent

33.7 (21.2–48.9)

 

43.6 (25.2–48.8)

 

10.9 (8.2–17.3)

 

8.7 (6.9–10.5)

 

Present

33.4 (25.6–52.6)

 

54.1 (40.3–52.7)

 

13.7 (10.5–19.5)

 

11.4 (8.2–12.9)

 
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