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Table 2 Computed tomography data of the study patients

From: CT-derived extracellular volume and liver volumetry can predict posthepatectomy liver failure in hepatocellular carcinoma

Variable

Training cohort (n = 181)

Internal validation cohort (n = 100)

External validation cohort (n = 112)

Without PHLF (n = 116)

With PHLF (n = 65)

p value

Without PHLF (n = 71)

With PHLF (n = 29)

p value

Without PHLF (n = 80)

With PHLF (n = 32)

p value

Liver cirrhosis (N)

50 (43.10%)

23 (35.38%)

0.310

22 (30.99%)

7 (24.14%)

0.493

34 (42.50%)

12 (37.50%)

0.627

Ascites (N)

11 (9.48%)

5 (7.69%)

0.684

8 (11.27%)

1 (3.45%)

0.393

8 (10.00%)

4 (12.50%)

0.961

CT-derived ECV

25.83 (23.26, 28.08)

29.78 (26.41, 32.94)

 < 0.001*

25.64 (23.25, 30.15)

31.03 (27.67, 34.93)

 < 0.001

26.03 (22.94, 28.11)

28.88 (27.46, 32.40)

 < 0.001

TV (cm3)

43.85 (12.85, 136.75)

67.20 (22.75, 419.00)

0.035*

35.00 (8.12, 226.00)

71.30 (24.25, 229.80)

0.676

37.83 (5.41, 247.28)

12.11 (3.96, 89.87)

0.130

TLV (cm3)

1262.00 (1046.75, 1521.00)

1348.00 (1205.50, 1574.00)

0.579

1242.88 (1025.56, 1508.00)

1303.00 (1112.33, 1535.00)

0.261

1401.00 (1171.00, 1571.00)

1411.50 (1255.75, 1586.25)

0.495

FLR volume (cm3)

924.42 ± 219.33

794.71 ± 212.56

 < 0.001*

874.40 ± 195.61

748.54 ± 213.63

0.005

956.98 ± 212.99

866.66 ± 151.06

0.031

mFLR ratio (%)

81.36 (78.26, 84.63)

66.27 (57.22, 79.85)

 < 0.001*

81.93 (79.52, 84.43)

61.22 (53.71, 66.05)

 < 0.001

79.89 (76.90, 83.11)

67.45 (61.03, 70.84)

 < 0.001

  1. Note: Data are presented as n (percentage), median (interquartile range), or mean ± standard deviation
  2. Abbreviations: PHLF Posthepatectomy liver failure, CT Computed tomography, ECV Extracellular volume, TLV Total liver volume, TV Tumor volume, FLR Future liver remnant, mFLR Measured FLR
  3. *The comparison between patients without PHLF and patients with PHLF in the training cohort. p value < 0.05 means significant