Table 2 Univariate and multivariate logistic regression analysis of risk factors associated with MYCN amplified in the training cohort
Characteristics | Univariate | Multivariate | ||
|---|---|---|---|---|
OR (95% CI) | p value | OR (95% CI) | p value | |
Clinical factors | ||||
Age at diagnosis (years, ≥ 18 mos) | 0.711 (0.279, 1.828) | 0.008 | - | - |
Gender (Male) | 2.081 (0.928, 4.736) | 0.045 | - | - |
NSE (ng/mL, high) | 1.004 (1.002, 1.005) | 0.020 | - | - |
SF (ng/mL, high) | 1.308 (0.591, 2.912) | < 0.001 | 1.484 (1.063–2.105) | 0.048 |
LDH (U/L, high) | 5.843 (2.452, 14.698) | < 0.001 | 5.825 (2.015, 18.489) | 0.002 |
VMA (μmol/L, high) | 0.897 (0.387, 2.106) | 0.800 | - | - |
HVA (μmol/L, high) | 1.361 (0.614, 3.059) | 0.449 | - | - |
INRGSS (M) | 1.770 (0.615, 5.489) | 0.294 | - | - |
Thoracic primary (Yes) | 0.664 (0.163, 1.248) | 0.171 | - | - |
Adrenal primary (Yes) | 1.535 (0.640, 3.870) | 0.691 | - | - |
Infiltrating across midline (Yes) | 3.325 (1.262, 9.337) | 0.015 | - | - |
Calcification (Yes) | 3.680 (1.362, 10.570) | 0.064 | - | - |
Necrosis (Yes) | 1.024 (0.353, 2.916) | 0.010 | 2.206 (0.747, 7.216) | 0.167 |
SUVmax (Median ± IQR) | 1.123 (0.969, 1.301) | 0.070 | - | - |
MTV (Median ± IQR, mL) | 1.001 (1.000, 1.002) | 0.006 | - | - |
TLG (Median ± IQR) | 1.001 (0.998, 1.004) | < 0.001 | 1.001 (1.000, 1.002) | 0.156 |
Rad score | 1.338 (0.342, 5.233) | < 0.001 | 13.515 (3.364, 36.802) | < 0.001 |