Insights into Imaging

Table 2 Comparison of DLCT quantitative parameters between different MSI status in training set and validation set

From: Dual-layer spectral-detector CT for predicting microsatellite instability status and prognosis in locally advanced gastric cancer

Parameters	Training set (n = 184)			Validation set (n = 80)
Parameters	MSI-H (n = 51)	MSI-L/MSS (n = 133)	p value^*	MSI-H (n = 51)	MSI-L/MSS (n = 133)	p value^*
Arterial phase
CT_{40keV_AP}, HU	120.07 (95.50, 150.99)	126.87 (109.36, 150.24)	0.290	115.49 (87.77, 152.19)	120.01 (86.74, 150.50)	0.950
CT_{70keV_AP}, HU	65.98 (55.98, 76.40)	66.19 (59.07, 78.82)	0.698	63.43 (55.15, 74.65)	64.24 (51.33, 76.52)	0.968
ID_AP, mg/ml	0.96 (0.70, 1.32)	0.99 (0.79, 1.42)	0.287	0.87 (0.74, 1.17)	0.91 (0.64, 1.27)	0.928
NID_AP	0.10 (0.08, 0.14)	0.11 (0.08, 0.16)	0.517	0.09 (0.06, 0.11)	0.10 (0.08, 0.13)	0.173
Zeff_AP	7.81 (7.67, 7.90)	7.83 (7.69, 8.03)	0.394	7.80 (7.65, 7.95)	7.80 (7.65, 8.03)	0.991
λHU_VP	1.37 (1.02, 1.55)	1.39 (1.06, 2.02)	0.340	1.21 (0.68, 1.42)	1.25 (0.85, 1.82)	0.494
Venous phase
CT_{40keV_VP}, HU	145.38 (124.25, 193.55)	167.37 (145.80, 198.73)	0.012	144.96 (130.04, 173.92)	177.77 (150.14, 197.73)	0.006
CT_{70keV_VP}, HU	79.20 (69.59, 90.48)	85.70 (73.49, 97.48)	0.035	73.82 (66.78, 85.00)	84.60 (74.21, 98.86)	0.026
ID _VP, mg/ml	1.11 (0.98, 1.42)	1.52 (1.34, 1.87)	< 0.001	1.21 (0.98, 1.38)	1.56 (1.39, 1.99)	< 0.001
NID_VP	0.26 (0.20, 0.29)	0.34 (0.28, 0.41)	< 0.001	0.23 (0.18, 0.29)	0.34 (0.28, 0.40)	< 0.001
Zeff_VP	7.87 (7.81, 7.99)	8.13 (8.05, 8.27)	< 0.001	7.83 (7.75, 7.95)	8.15 (8.07, 8.35)	< 0.001
λHU_VP	1.31 (0.90, 1.81)	2.19 (1.78, 2.92)	< 0.001	1.50 (1.18, 2.98)	2.30 (1.82, 2.97)	0.002

Data are given as median (inter-quartile ranges)
AP Arterial phase, DLCT Dual-layer spectral detector CT, ID Iodine density, λHU The slope of the spectral curve, MSI Microsatellite instability, MSI-H Microsatellite instability high, MSI-L/MSS Microsatellite instability low or microsatellite stable, NID Normalized iodine density, VP Venous phase, Zeff Effective atomic number
^*p value represents comparison between MSI-H group and MSI-L/MSS group

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