Table 4 Diagnostic performance of CT based on the clinical significance (per-patient analysis)
Expertise | Sensitivity% (95% CI) | Specificity% (95% CI) | NPV% (95% CI) | PPV% (95% CI) | Accuracy% (95% CI) | TP | TN | FP | FN |
|---|---|---|---|---|---|---|---|---|---|
(a) Evaluation based on CHAARTED (Initial staging) | |||||||||
Junior radiologist | 63.6 (49.6–76.2) | 98.1 (94.5–99.6) | 88.4 (84.4–91.6) | 92.1 (78.9–97.3) | 88.6 (83.6–92.6) | 35 | 153 | 3 | 20 |
Nuclear medicine | 60.3 (46.6–73.0) | 98.7 (95.3–99.7) | 86.8 (82.7–90.0) | 94.6 (81.3–98.6) | 87.7 (82.5–91.8) | 35 | 151 | 2 | 23 |
Senior radiologist | 71.2 (56.9–82.9) | 99.4 (96.6–100) | 91.3 (87.3–94.2) | 97.4 (83.9–99.6) | 92.4 (88.0–95.6) | 37 | 158 | 1 | 15 |
(b) Evaluation based on LATITUDE (Initial staging) | |||||||||
Junior radiologist | 67.2 (53.7–79.0) | 98.7 (95.4–99.8) | 88.8 (85.0–92.0) | 95.1 (83.0–98.7) | 90.1 (85.2–93.7) | 39 | 151 | 2 | 19 |
Nuclear medicine | 62.3 (49.0–74.4) | 98.7 (95.3–99.8) | 86.6 (82.3–89.9) | 95 (82.6–98.7) | 88.2 (82.3–89.9) | 38 | 148 | 2 | 23 |
Senior radiologist | 76.4 (63.0–86.8) | 99.4 (96.5–100) | 92.3 (88.1–95.0) | 97.7 (85.6–99.7) | 93.4 (89.1–96.3) | 42 | 155 | 1 | 13 |
(c) Osteo-metastasis evaluation in biochemical recurrent patients | |||||||||
Junior radiologist | 72.9 (62.9–81.5) | 95.9 (93.0–97.9) | 91.6 (88.6–93.8) | 85.4 (78.8–91.1) | 90.3 (86.9–93.0) | 70 | 282 | 12 | 26 |
Nuclear medicine | 70.4 (60.3–79.2) | 98.6 (96.5–99.6) | 90.9 (88.0–93.1) | 94.5 (86.6–97.9) | 91.5 (88.3–94.1) | 69 | 288 | 4 | 29 |
Senior radiologist | 81.3 (71.8–88.7) | 98.3 (96.1–99.5) | 94.4 (91.8–96.4) | 93.7 (86.1–97.3) | 94.4 (91.6–96.4) | 74 | 294 | 5 | 17 |