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Table 1 Indications recommended by the National Comprehensive Cancer Network 2021, the European Society of Gynecological Oncology guidelines 2021 and the International Federation of Gynecology and Obstetrics cancer report 2018 for fertility-sparing treatment

From: Radiomics-based fertility-sparing treatment in endometrial carcinoma: a review

Guidelines

Histopathologic types and grades

MI

MRI/USa

Dilatation and curettage or endometrial biopsya

Informed consentb

Close follow-up

Outcomesc

National Comprehensive Cancer Network 2021

Grade 1 endometrial adenocarcinoma

No

Yes

Yes

Yes

Yes

TH/BSO

European Society of Gynecological Oncology guidelines 2021

Grade 1 endometrioid carcinoma or atypical hyperplasia/endometrioid intra-epithelial neoplasia

No

Yes

Yes

Yes

Yes

TH/BSO

International Federation of Gynecology and Obstetrics cancer report 2018

Grade 1 endometrioid carcinoma

No

Yes

-

Yes

Yes

TH/BSO

  1. Patients who meet the above conditions should exclude pregnancy and consult a reproductive specialist before treatment. Genetic counseling and genetic testing are necessary for appropriate patients
  2. MI, myometrial invasion; MRI, magnetic resonance imaging; US, ultrasound; TH/BSO, total hysterectomy and bilateral salpingo-oophorectomy
  3. aTo evaluate the extension of disease
  4. bFertility-sparing treatment is a non-standard treatment, which must be known for patients
  5. cTH/BSO is recommended in the end, whether the treatment is successful or not