Magnetic resonance imaging for treatment response evaluation and prognostication of hepatocellular carcinoma after thermal ablation

Zhang, Yun; Wei, Hong; Song, Bin

doi:10.1186/s13244-023-01440-7

Insights into Imaging

Table 1 Summary of published studies focusing on magnetic resonance imaging for treatment response evaluation and prognostication of hepatocellular carcinoma after thermal ablation

From: Magnetic resonance imaging for treatment response evaluation and prognostication of hepatocellular carcinoma after thermal ablation

Reference	Publication year	Study design	Area	No. of patients	No. and type of lesions	Imaging modality	Study endpoints	Ablation modality
Sheng et al. [14]	2015	Retrospective, single-center	China	35	40 HCCs	ECA-MRI	Prediction of IDR	RFA
Hermida et al. [15]	2021	Retrospective, single-center	France	238	412 HCCs	CEMRI; CECT	Evaluation of LTP, Time-to-LTP, IDR, Time-to-IDR, RFS and OS	RFA; MWA
Hermida et al. [16]	2020	Retrospective, single-center	France	235	419 HCCs	ECA-MRI	Evaluation of TTR, RFS and OS	RFA; MWA
Chaudhry et al. [18]	2020	Retrospective, single-center	USA	36	53 HCCs	ECA-MRI	Evaluation of the performance of LI-RADS version 2018 TRA	RFA; MWA
Bae et al. [19]	2021	Retrospective, single-center	Korea	183	HCC^†	EOB-MRI	Prediction of DFS and OS	RFA
Cha et al. [20]	2021	Retrospective, single-center	Korea	349	349 HCCs	EOB-MRI	Evaluation of early recurrence	RFA
Kang et al. [21]	2016	Retrospective, single-center	Korea	211	211 HCCs	EOB-MRI	Prediction of LTP	RFA
Cools et al. [22]	2020	Retrospective, single-center	USA	45	81 HCCs	EOB-MRI	Validation of LI-RADS version 2018 TRA	RFA; MWA
Lee et al. [26]	2015	Retrospective, single-center	Korea	139	178 HCCs	EOB-MRI	Prediction of Recurrence	RFA
Toyoda et al. [27]	2015	Prospective, single-center	Japan	138	HCC^†	EOB-MRI	Prediction of Recurrence	RFA
Iwamoto et al. [28]	2017	Retrospective, single-center	Japan	91	115 HCCs	EOB-MRI	Prediction of IDR	RFA
Inoue et al. [29]	2017	Retrospective, single-center	Japan	132	HCC^†	EOB-MRI	Prediction of IDR	RFA
Lee et al. [34]	2019	Retrospective, single-center	Korea	345	345 HCCs	EOB-MRI	Evaluation of RFS	RFA
Koda et al. [39]	2015	Prospective, single-center	Japan	95	124 HCCs	EOB-MRI	Evaluation of LTP	RFA
Takeyama et al. [40]	2019	Retrospective, single-center	Japan	29	59 HCCs	EOB-MRI	Prediction of LTP	RFA
Lee et al. [41]	2020	Retrospective, single-center	Korea	467	467 HCCs	CEMRI; CECT	Evaluation of LTP and OS	RFA
Kawamura et al. [45]	2019	Retrospective, single-center	Japan	488	488 HCCs	ECA-MRI; CECT	Prediction of intrasubsegmental recurrence	RFA
Kondo et al. [46]	2011	Prospective, single-center	Japan	589	HCC^†	ECA-MRI; CECT	Evaluation of recurrence and survival	RFA
Kim et al. [47]	2017	Prospective, single-center	Korea	33	42 HCCs	ECA-MRI; CECT	Evaluation of LTP	RFA
Mori et al. [49]	2015	NA	Japan	136	168 HCCs	DWI	Evaluation of recurrence and survival	RFA
Ma et al. [50]	2019	Retrospective, single-center	China	64	HCC^†	DWI	Prediction of tumor progression	RFA
Barat et al. [51]	2017	Retrospective, dual-center	France	59	38 HCCs; 27 metastases	DWI	Evaluation of local tumor recurrence	RFA
Hu et al. [52]	2020	Retrospective, single-center	China	105	HCC^†	ECA-MRI	Prediction of LTP	RFA
Yuan et al. [55]	2019	Retrospective, single-center	China	107	107 HCCs	DKI; DWI	Prediction of recurrence	RFA
Kobe et al. [57]	2021	Retrospective, single-center	Switzerland	39	43 HCCs	ECA-MRI; Perfusion CT	Evaluation of local tumor recurrence	RFA
Yoon et al. [58]	2018	Prospective, single-center	Korea	68	88 HCCs	EOB-MRI; CECT	Evaluation of LTP	RFA
Wang et al. [59]	2020	Retrospective, single-center	China	115	115 HCCs	EOB-MRI; CEUS	Evaluation of recurrence	RFA
Horvat et al. [60]	2021	Retrospective, single-center	Brazil	34	51 LR-4/5 nodules	ECA-MRI	Prediction of sustained complete response	RFA
Petukhova-Greenstein et al. [61]	2022	Retrospective	Germany	65	85 HCCs	ECA-MRI	Prediction of PFS	RFA
Wen et al. [62]	2021	Retrospective, single-center	China	111	HCC^†	GD-MRI	Prediction of early recurrence	RFA
Lv et al. [63]	2021	Retrospective, single-center	China	58	HCC^†	ECA-MRI	Prediction of aggressive intrasegmental recurrence	RFA

CECT contrast-enhanced computed tomography; CEMRI contrast-enhanced magnetic resonance imaging; CEUS contrast-enhanced Ultrasound; CT computed tomography; DFS disease-free survival; DKI diffusion kurtosis imaging; DWI diffusion-weighted imaging; ECA-MRI extracellular contrast agent-enhanced magnetic resonance imaging; EOB-MRI gadoxetate disodium-enhanced magnetic resonance imaging; GD-MRI gadobenate dimeglumine-enhanced magnetic resonance imaging; HCC hepatocellular carcinoma; IDR intrahepatic distant recurrence; LI-RADS/LR Liver Imaging Reporting and Data System; LTP local tumor progression; MRI magnetic resonance imaging; MWA microwave ablation; NA not available; OS overall survival; PFS progression-free survival; RFA radiofrequency ablation; RFS recurrence-free survival; SPIO superparamagnetic iron oxide; TRA treatment response algorithm; TTR time to recurrence
^†The number of HCC is unavailable

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