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Insights into Imaging

Table 1 Univariate logistic regression analysis of training and testing sets characteristics

From: A virtual biopsy study of microsatellite instability in gastric cancer based on deep learning radiomics

 

Training set (n = 167)

Testing set (n = 56)

Clinical characteristics

MSS/MSI-L (N = 142)

MSI/MSI-H (N = 25)

p value

MSS/MSI-L (N = 40)

MSI/MSI-H (N = 16)

p value

Gender:

  

0.015

  

0.129

 Female

33 (23.2)

12 (48.0)

 

11 (27.5)

8 (50.0)

 

 Male

109 (76.8)

13 (52.0)

 

29 (72.5)

8 (50.0)

 

Age (years):

63.29 ± 9.59

68.12 ± 5.95

0.016

61.03 ± 10.40

64.25 ± 8.58

0.277

Clinical T stage:

  

0.025

  

0.009

 I

2 (1.4)

6 (24.0)

 

0 (0)

4 (25.0)

 

 II

21 (14.8)

2 (8.0)

 

5 (12.5)

1 (6.2)

 

 III

87 (51.5)

16 (64.0)

 

21 (52.5)

9 (56.3)

 

 IV

32 (32.3)

1 (4.0,)

 

14 (35.0)

2 (12.5)

 

Differentiated degree

  

0.013

  

0.001

 Well-differentiated

2 (1.4)

1 (4.0)

 

0 (0)

0 (0)

 

 Moderately differentiated

42 (29.6)

14 (56.0)

 

13 (32.5)

13 (81.3)

 

 Poorly differentiated

98 (69.0)

10 (40.0)

 

27 (67.5)

3 (18.7)

 

Tumor location:

  

0.765

  

0.189

 Upper-third

22 (15.5)

2 (8.0)

 

6 (15.0)

0 (0)

 

 Middle-third

33 (23.2)

6 (24.0)

 

10 (25.0)

2 (12.5)

 

 Lower-third

83 (58.5)

16 (64.0)

 

23 (57.5)

13 (81.3)

 

 Multiple

4 (2.8)

1 (4.0)

 

1 (2.5)

1 (6.2)

 

Bowman type

  

0.460

  

0.365

 I

5 (3.8)

2 (8.3)

 

0 (0)

1 (6.7)

 

 II

11 (8.3)

1 (4.2)

 

5 (12.5)

3 (20.0)

 

 III

114 (85.7)

20 (83.3)

 

33 (82.5)

11 (73.3)

 

 IV

3 (2.2)

1 (4.2)

 

2 (5.0)

0 (0)

 

CEA level (ng/mL)

  

0.658

  

0.763

 Normal

86 (61.4)

16 (66.7)

 

25 (62.5)

11 (68.8)

 

 Abnormal

54 (38.6)

8 (33.3)

 

15 (37.5)

5 (31.3)

 

AFP level (ng/mL)

  

1.000

  

0.550

 Normal

131 (93.6)

23 (95.8)

 

37 (92.5)

16 (100.0)

 

 Abnormal

9 (6.4)

1 (4.2)

 

3 (7.5)

0 (0)

 

CA19-9 level (u/mL)

  

1.000

  

0.416

 Normal

123 (88.5)

21 (91.3)

 

33 (89.2)

15 (93.8)

 

 Abnormal

16 (11.5)

3 (8.7)

 

4 (10.8)

1 (6.2)

 

 ALB (g/L)

40.10 ± 5.04

40.53 ± 4.82

0.698

40.21 ± 4.70

39.21 ± 5.57

0.501

 NE (10^9/L)

3.44 (2.71–4.52)

4.72 (2.68–5.51)

0.061

3.46 (2.52–4.65)

3.67 (2.72–5.10)

0.737

 Lym (10^9/L)

1.67 (1.37–2.00)

1.88 (1.07–2.47)

0.474

1.66 (1.37–2.07)

1.50 (1.00–2.50)

0.544

 NLR

1.96 (1.54–2.91)

2.33 (1.99–3.19)

0.230

2.07 (1.91–2.83)

1.77 (1.02–3.23)

0.154

  1. All p values <0.05 are bolded in Table, which were considered statistically significant in the corresponding correlation analysis
  2. Data for continuous variables are expressed as median (interquartile range) or mean ± standard deviation, and categorical variables are expressed as sample size (%). AFP Alpha fetal protein; ALB Albumin; CEA Carcinoembryonic antigen; CA19-9 Carbohydrate antigen 19–9; Lym Lymphocyte count; NE Neutrophil count; NLR Neutrophil lymphocyte ratio
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