Pretreatment synthetic magnetic resonance imaging predicts disease progression in nonmetastatic nasopharyngeal carcinoma after intensity modulation radiation therapy

Insights into Imaging

Table 4 Performance of quantitative SyMRI and DWI parameters in the prediction of 3-year disease progression

	Cutoff value	AUC (95% CI)	Sensitivity (%)	Specificity (%)	Accuracy (%)	PPV	NPV
SyMRI model
T1_Kurtosis	6.98	0.748 (0.590, 0.907)	81.3	64.9	73.6	0.625	0.756
DWI model
ADC	868.00	0.716 (0.564, 0.868)	68.8	73.0	71.7	0.571	0.739
Clinic model T stage	T1 stage	0.635 (0.485, 0.785)	100.0	27.0	69.8	0	0.698
SyMRI + DWI + Clinic model T1_Kurtosis + ADC + T stage	0.29	0.846 (0.731, 0.961)	81.2	75.7	81.1	0.818	0.833

SyMRI Synthetic magnetic resonance imaging; DWI Diffusion-weighted imaging; PD Proton density; ADC Apparent diffusion coefficient; AUC Area under the curve; 95% CI 95% confidence interval
Logit (SyMRI) = 0.18 × T1_Kurtosis − 2.471; Logit (SyMRI + DWI + Clinic) = 0.136 × T1_Kurtosis + 0.008 × ADC + 20.643 × T stage − 29.05