Insights into Imaging

Table 4 Sensitivities and specificities obtained by the three groups of readers using PI-RADSv2.1 and PI-RADSv2 scoring

From: Characterization of high-grade prostate cancer at multiparametric MRI: assessment of PI-RADS version 2.1 and version 2 descriptors across 21 readers with varying experience (MULTI study)

			Threshold ≥ 3				Threshold ≥ 4
			Se [95% CI]	p⁽¹⁾	Sp [95% CI]	p⁽²⁾	Se [95% CI]	p⁽¹⁾	Sp [95% CI]	p⁽²⁾
Predefined lesions (N = 240)	PI-RADSv2.1	Experienced seniors	93 [85–97]	0.61	33 [19–52]	0.15	85 [76–92]	0.97	51 [36–65]	0.36
		Less experienced seniors	98 [95–99]	0.12	13 [7–25]	0.44	91 [85–95]	0.19	26 [16–40]	0.10
		Juniors	94 [88–98]	-	19 [10–33]	-	86 [76–92]		42 [28–56]	-
	PI-RADSv2	Experienced seniors	94 [89–97]	0.08	24 [15–38]		87 [79–92]	0.74	45 [31–59]	0.06
		Less experienced seniors	98 [95–99]	0.66	11 [6–20]		93 [88–96]	0.18	24 [15–36]	0.87
		Juniors	97 [95–99]	-	12 [7–21]		88 [81–93]	-	36 [24–50]	-
Per-lobe analysis (N = 318)	PI-RADSv2.1	Experienced seniors	90 [86–94]	0.63	48 [39–58]	0.08	85 [78–90]	0.90	62 [51–72]	0.34
		Less experienced seniors	92 [88–95]	0.84	38 [29–47]	0.88	87 [81–92]	0.44	48 [37–59]	0.39
		Juniors	92 [87–95]	-	37 [28–46]	-	84 [78–90]	-	55 [44–66]	-
	PI-RADSv2	Experienced seniors	91 [88–94]	0.34	42 [34–50]	0.06	87 [81–91]	0.99	56 [46–67]	0.36
		Less experienced seniors	93 [90–95]	0.73	34 [27–43]	0.54	89 [84–93]	0.54	45 [35–56]	0.55
		Juniors	93 [90–95]	-	31 [24–39]	-	87 [81–91]	-	50 [39–60]	-

(1) p value comparing the sensitivity to that of junior readers
(2) p value comparing the specificity to that of junior readers
Sensitivities and specificities are expressed in percentages

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