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Table 2 Diagnostic performance of liver stiffness and spleen stiffness to detect hepatic fibrosis

From: Magnetic resonance elastography in evaluation of liver fibrosis in children with chronic liver disease

 

Fibrosis stage

n

Cut-off (kPa)

AUC (95% CI)

p

Sensitivity (95% CI)

Specificity (95% CI)

PPV (95% CI)

NPV (95% CI)

Accuracy

Liver stiffness (n = 52)

 > F0

49

2.65

0.63 (0.49–0.85)

0.302

40.8 (27–55.8)

100 (29.2–100)

100 (83.2–100)

9.4 (2–25)

44.2

 > F1

35

2.14

0.76 (0.62–0.87)

 < 0.001

91.4 (76.9–98.2)

58.8 (32.9–81.6)

82.1 (66.5–92.5)

76.9 (46.2–95)

80.8

 > F2

24

2.8

0.74 (0.56–0.85)

 < 0.001

58.3 (36.6–77.9)

85.7 (67.3–96)

77.8 (52.4–93.6)

70.6 (52.5–84.9)

73.1

 > F3

11

2.97

0.90 (0.79–0.97)

 < 0.001

90.9 (58.7–99.8)

82.9 (67.9–92.8)

58.8 (32.9–81.6)

97.1 (85.1–99.9)

84.6

 > F4

5

3.14

0.89 (0.78–0.96)

 < 0.001

100 (47.8–100)

80.9 (66.7–90.9)

35.7 (12.8–64.9)

100 (90.7–100)

82.7

 > F5

4

3.14

0.86 (0.74–0.94)

 < 0.001

100 (39.8–100)

79.2 (65–89.5)

28.6 (8.4–58.1)

100 (90.7–100)

80.8

Spleen stiffness (n = 49)

 > F0

46

0.5

0.64 (0.49–0.77)

0.526

100 (92.3–100)

33.3 (0.8–90.6)

95.8 (85.7–99.5)

100 (2.5–100)

95.9

 > F1

34

2.87

0.64 (0.49–0.77)

0.112

73.5 (55.6–87.1)

53.3 (26.6–78.7)

78.1 (60–90.7)

47.1 (23–72.2)

67.3

 > F2

23

3.38

0.69 (0.55–0.82)

0.010

73.9 (51.6–89.8)

57.7 (36.9–76.6)

60.7 (40.6–78.5)

71.4 (47.8–88.7)

65.3

 > F3

11

6.26

0.68 (0.54–0.81)

0.083

45.5 (16.7–76.6)

94.7 (82.3–99.4)

71.4 (29–96.3)

85.7 (71.5–94.6)

83.7

 > F4

5

8.66

0.82 (0.69–0.92)

0.002

60 (14.7–94.7)

97.7 (88–99.9)

75 (19.4–99.4)

95.6 (84.9–99.5)

93.9

 > F5

4

3.42

0.78 (0.64–0.89)

0.030

100 (39.8–100)

48.9 (33.7–64.2)

14.8 (4.2–33.7)

100 (84.6–100)

53.1