Reproducibility of 2D versus 3D radiomics for quantitative assessment of fetal lung development: a retrospective fetal MRI study

Insights into Imaging

Table 2 Radiomics feature reproducibility

MRI acquisitions	First order statistics		Shape features		Texture features
MRI acquisitions	ICC > 0.9	ICC ≤ 0.9	ICC > 0.9	ICC ≤ 0.9	ICC > 0.9	ICC ≤ 0.9
Single
2D versus 3D ROI	5/18 (27.8%)	13/18 (72.2%)	0/9 (0%)	9/9 (100%)	0/68 (0%)	68/68 (100%)
Repeated
2D versus 2D ROI	7/18 (38.9%)	11/18 (61.1%)	4/9 (44.4%)	5/9 (55.6%)	1/68 (1.5%)	67/68 (98.5%)
3D versus 3D ROI	10/18 (55.6%)	8/18 (44.4%)	7/9 (77.8%)	2/9 (22.2%)	32/68 (47.1%)	36/68 (52.9%)

Summary of radiomics feature reproducibility for the use of two-and three-dimensional regions of interest in a single and in repeated MRI acquisitions. Excellent reproducibility was defined as intra-class correlation coefficient > 0.9. Texture features include the following classes: Grey Level Co-occurrence Matrix, Grey Level Size Zone Matrix, Grey Level Run Length Matrix, and Grey Level Dependence Matrix
ICC intra-class correlation coefficient, ROI region of interest