CT and MR imaging features of mixed neuroendocrine–non-neuroendocrine neoplasm of the pancreas compared with pancreatic ductal adenocarcinoma and neuroendocrine tumor

Insights into Imaging

Table 1 Clinicopathological characteristics of patients with pancreatic MiNEN, PDAC, and NET

Characteristic	MiNEN (n = 12)	PDAC (n = 24)	NET (n = 24)	p value^a
Age (year)
Mean ± SD	55.8 ± 11.1	58.9 ± 13.8	50.6 ± 14.5	0.331
Range	37–73	36–83	31–72
Sex				> 0.999
Male	8	16	16
Female	4	8	8
Location				0.402
Body and tail	8	11	10
Head and neck	4	13	14
Clinical manifestation				–
Abdominal pain or discomfort	9	22	8
Jaundice	2	4	0
Serum CA19-9				0.015
Normal (< 35 U/mL)	8	13	22
Elevated (35–994.2 U/mL)	4	11	2
Serum amylase				> 0.999
Normal (40–110 U/L)	9	19	18
Elevated (111–383 U/L)	3	5	6
Surgery				< 0.001
Pancreaticoduodenectomy	3	12	6
Distal pancreatectomy	7	6	8
Local tumor resection	2	0	10
Palliative surgery	0	6	0

Continuous variables are expressed as the mean ± standard deviation, and categorical variables are described as the number of patients
MiNEN, mixed neuroendocrine–non-neuroendocrine neoplasm; PDAC, pancreatic ductal adenocarcinoma; NET, neuroendocrine tumor; CA 19-9, carbohydrate antigen 19-9
^aComparison among MiNEN, PDAC, and NET