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Table 4 Clinical and CMR predictors of MACE in multivariable cox regression analysis for all patients

From: Prognostic significance of non-infarcted myocardium correlated with microvascular impairment evaluated dynamically by native T1 mapping

Model

Multivariable analysis

LR Chi-square (p value)

Variable

Adj HR (95% CI)

p value

Model 1

19.26 (p < 0.001)

Killip class

–

–

  

cTnImax

–

–

  

BNPmax

–

–

  

CRPmax

1.01 (1, 1.03)

0.043

  

TIMI flow grade post-PCI

–

–

  

LVEDV

–

–

  

LVESV

–

–

  

iLVESV

–

–

  

Transmural infarction

–

–

  

Pericardial effusion

–

–

  

MVO

–

–

  

IMH

–

–

  

LVEF1w

0.94 (0.90, 0.97)

 < 0.001

Model 2

69.31 (p < 0.001)

Killip class

–

–

  

cTnImax

–

–

  

BNPmax

–

–

  

CRPmax

–

–

  

TIMI flow grade post-PCI

0.30 (0.15, 0.60)

0.001

  

LVEDV

–

–

  

LVESV

1.01 (1, 1.02)

0.012

  

iLVESV

–

–

  

Transmural infarction

–

–

  

Pericardial effusion

–

–

  

MVO

–

–

  

IMH

–

–

  

LVEF1w

–

–

  

Native1w T1

1.03 (1.02, 1.05)

 < 0.001

  

Native30D T1

1.05 (1.03, 1.07)

 < 0.001

Model 3

44.88 (p < 0.001)

Killip class

1.85 (1.13, 3.03)

0.015

  

cTnImax

–

–

  

BNPmax

–

–

  

CRPmax

1.02 (1.01, 1.04)

0.004

  

TIMI flow grade post-PCI

–

–

  

LVEDV

–

–

  

LVESV

–

–

  

iLVESV

–

–

  

Transmural infarction

–

–

  

Pericardial effusion

–

–

  

MVO

–

–

  

IMH

–

–

  

LGE1w

1.11 (1.06, 1.16)

 < 0.001

Model 4

79.42 (p < 0.001)

Killip class

–

–

  

cTnImax

–

–

  

BNPmax

–

–

  

CRPmax

–

–

  

TIMI flow grade post-PCI

–

–

  

LVEDV

–

–

  

LVESV

–

–

  

iLVESV

–

–

  

Transmural infarction

–

–

  

Pericardial effusion

–

–

  

MVO

–

–

  

IMH

–

–

  

LGE1w

1.10 (1.05, 1.15)

 < 0.001

  

Native1w T1

1.03 (1.01, 1.04)

0.002

  

Native30D T1

1.05 (1.03, 1.07)

 < 0.001

Model 5

55.75 (p < 0.001)

Native1w T1

1.03 (1.02, 1.05)

 < 0.001

  

Native30D T1

1.05 (1.03, 1.06)

 < 0.001

  

Killip class

–

–

  

BNPmax

–

–

  

TIMI flow grade post-PCI

4.28 (1.83, 10.04)

0.001

  

IMH

–

–

  1. Adj HR, adjusted hazard ratio; BNPmax, peak brain natriuretic peptide; MVO, microvascular obstruction; IMH, intramyocardial hemorrhage; LVEF, left ventricular ejection fraction; LGE, late gadolinium enhancement; LGE1w was correlated with LVEF1w significantly (r = 0.60, p < 0.001); IMH was significantly correlated with cTnI (r = 0.62, p < 0.001) and MVO (r = 0.82, p < 0.001), respectively; TIMI flow grade post-PCI (1–2); and TIMI flow grade was 1 or 2 after primary PCI