A feasibility study of reduced full-of-view synthetic high-b-value diffusion-weighted imaging in uterine tumors

Insights into Imaging

Table 6 Diagnosis performance on cervical cancer of histogram-derived synthetic 13b-protocol and 5b-protocol ADC values with a b value of 0 and 1500 s/mm²

Parameters	AUC (95%CI)	Sensitivity (%)	Specificity (%)	p value	Threshold (s/mm²)
syADC_13b,mean	0.992 (0.979–1.000)	97.2	97.2	p < 0.05	0.923 × 10^–3
syADC_5b,mean	0.984 (0.958–1.000)	97.1	97.1	p < 0.05	0.910 × 10^–3
syADC_13b,minimum	0.963 (0.923–1.000)	91.7	91.7	p < 0.05	0.672 × 10^–3
syADC_5b,minimum	0.962 (0.917–1.000)	94.3	94.3	p < 0.05	0.645 × 10^–3
syADC_13b,skewness	0.465 (0.349–0.620)	86.1	22.2	p = 0.33	− 0.393
syADC_5b,skewness	0.460 (0.322–0.597)	11.4	71.4	p = 0.07	− 0.242
syADC_13b,kurtosis	0.451 (0.317–0.586)	100	5.6	p = 0.32	− 0.986
syADC_5b,kurtosis	0.355 (0.255–0.485)	45.7	25.7	p = 0.07	− 0.522

p values < 0.05 were considered statistically significant and are shown in bolded font
AUC = area under the receiver operating characteristic curve, 95%CI = 95% confidence intervals, syADC = synthetic apparent diffusion coefficient