Added value of histogram analysis of ADC in predicting radiation-induced temporal lobe injury of patients with nasopharyngeal carcinoma treated by intensity-modulated radiotherapy

Insights into Imaging

Table 4 Predictive performances of two models in predicting the radiation-induced temporal lobe injury in the training and validation cohort

Model	AUC	95% CI		Sensitivity	Specificity	PPV	NPV
Model		Lower	Upper	Sensitivity	Specificity	PPV	NPV
Model—ADC
Training cohort	0.95	0.91	0.98	0.85 (64/75)	0.93 (56/60)	0.94 (64/68)	0.83 (56/67)
Validation cohort	0.89	0.81	0.97	0.75 (24/32)	0.89 (42/47)	0.83 (24/29)	0.89 (42/47)
Model—combined
Training cohort	0.96	0.92	0.99	0.88 (66/75)	0.93 (56/60)	0.94 (66/70)	0.86 (56/65)
Validation cohort	0.87	0.78	0.96	0.81 (26/32)	0.82 (41/50)	0.81 (26/32)	0.87 (41/47)

AUC = area under the receiver operating characteristic curve, CI = confidence interval, NPV = negative predictive value, PPV = positive predictive value. *Features used for the Model-ADC are kurtosis, maximum, range, and total energy