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Table 2 The DCE-US features of patients between high Ki-67 expression and low Ki-67 expressing group

From: Prediction of the Ki-67 marker index in hepatocellular carcinoma based on Dynamic Contrast-Enhanced Ultrasonography with Sonazoid

Characteristic

High Ki-67 expression (n = 84)

Low Ki-67 expressing (n = 36)

p

DCE-US

HCC lesions

CAT (s)

13.4 ± 17.4

14.9 ± 16.5

0.673

FT (s)

21.9 ± 30.0

16.7 ± 25.1

0.369

HDT (s)

74.6 ± 33.4

74.2 ± 38.7

0.955

PE in arterial phase (a.u.)

1.3 × 108 ± 1.0 × 108

1.1 × 108 ± 9.7 × 107

0.414

RT (s)

17.5 ± 26.5

22.5 ± 30.2

0.521

TTP (s)

30.6 ± 27.4

34.6 ± 28.6

0.762

WiAUC

1.2 × 109 ± 1.3 × 109

1.1 × 109 ± 1.1 × 109

0.819

WiR (a.u./s)

2.6 × 107 ± 1.0 × 108

2.4 × 108 ± 1.2 × 109

0.089

WiWoAUC

3.9 × 109 ± 2.9 × 109

3.2 × 109 ± 4.3 × 109

0.425

WoAUC

2.8 × 109 ± 3.9 × 109

2.1 × 109 ± 3.6 × 109

0.405

WoR (a.u./s)

 − 6.3 × 106 ± 8 × 106

 − 7.3 × 106 ± 9.0 × 106

0.593

mTT (s)

15.4 ± 16.4

14.9 ± 13.8

0.891

PE in Kupffer phase (a.u.)

3.5 × 107 ± 4.4 × 107

7.5 × 107 ± 2.8 × 108

0.224

Difference between HCC lesions and distal liver parenchyma

CAT (s)

 − 3.6 ± 20.7

 − 3.2 ± 11.3

0.918

FT (s)

16.0 ± 34.7

17.1 ± 39.5

0.879

HDT (s)

 − 2.1 ± 28.4

0.4 ± 14.4

0.630

PE in arterial phase (a.u.)

2.4 × 107 ± 8.8 × 107

2.5 × 106 ± 8.1 × 107

0.208

RT (s)

 − 10.3 ± 30.9

 − 9.2 ± 30.8

0.857

TTP (s)

 − 13.7 ± 31.3

 − 12.1 ± 27.8

0.791

WiAUC

 − 2.3 × 105 ± 1.2 × 105

 − 9.8 × 105 ± 5.0 × 107

0.111

WiR (a.u./s)

1.8 × 106 ± 2.2 × 107

4.6 × 105 ± 1.2 × 107

0.738

WiWoAUC

1.0 × 109 ± 5.2 × 109

 − 7.2 × 108 ± 4.3 × 109

0.082

WoAUC

1.3 × 109 ± 4.1 × 109

2.3 × 108 ± 3.5 × 109

0.179

WoR (a.u./s)

 − 7.6 × 107 ± 6.9 × 108

 − 5.4 × 107 ± 3.2 × 106

0.124

mTT (s)

 − 0.4 ± 23.2

 − 0.1 ± 16.4

0.939

PE in Kupffer phase (a.u.)

 − 3.4 × 106 ± 4.8 × 107

 − 1.8 × 107 ± 3.4 × 107

0.045

  1. CAT contrast agent arrival time; PE peak energy; TTP time to peak; RT rise time; WiR wash-in area under the curve; WiAUC wash-in area under the curve; HDT half decrease time; FT fall time; WoR wash-out rate; WoAUC wash-out area under the curve; mTT mean transit time; WiWoAUC WiWoAUC + WiAUC