Table 1 The features of patients between high Ki-67 expression and low Ki-67 expressing group
Characteristic | High Ki-67 expression (n = 84) | Low Ki-67 expressing (n = 36) | p |
|---|---|---|---|
Clinicopathological features | |||
Gender | |||
Male, n (%) | 75 | 35 | 0.149 |
Age, mean ± SD, years | 54.0 ± 11.4 | 57.8 ± 10.4 | 0.093 |
Cirrhosis, n (%) | 56 | 28 | 0.224 |
HBsAg-positive, n (%) | 69 | 31 | 0.593 |
AFP, ng/ml | 2055.3 ± 7778.5 | 109.7 ± 292.9 | 0.137 |
CEA, ng/ml | 2.7 ± 1.5 | 3.4 ± 2.3 | 0.087 |
CA19-9, ng/ml | 53.0 ± 271.2 | 16.5 ± 12.3 | 0.487 |
CA125, ng/ml | 14.1 ± 13.7 | 14.5 ± 7.2 | 0.935 |
Alanine aminotransferase, U/L | 33.7 ± 25.9 | 31.0 ± 21.3 | 0.578 |
Aspartate aminotransferase, U/L | 37.1 ± 35.2 | 28.2 ± 10.8 | 0.139 |
Total bilirubin, U/L | 16.0 ± 26.2 | 13.0 ± 6.2 | 0.497 |
Edmondson-Steiner grade ( I-II, III-IV) | 18:66 | 16:20 | 0.010 |
Microvascular invasion | 23 | 3 | 0.020 |
Imaging features | |||
Location (right lobe, left lobe, caudal lobe) | 56:27:1 | 22:13:1 | 0.734 |
Echo (high, low) | 20:64 | 28:8 | 0.851 |
Tumor size (cm) | 5.1 ± 2.9 | 4.5 ± 2.3 | 0.001 |
Blood flow signal (yes, no) | 68:18 | 26:10 | 0.451 |
Inner diameter of main portal vein (cm) | 1.2 ± 0.1 | 1.2 ± 0.2 | 0.770 |
CEUS | |||
Arterial phase (hype, iso, hypo-enhancement) | 82:2:0 | 34:1:1 | 0.305 |
Portal phase (hype,iso,hypo-enhancement) | 5:55:24 | 5:19:12 | 0.252 |
Delayed phase (hype,iso,hypo-enhancement) | 0:8:76 | 0:5:31 | 0.481 |
Kupffer phase (hype,iso,hypo-enhancement) | 0:1:83 | 0:1:35 | 0.534 |