Enhancing cancer differentiation with synthetic MRI examinations via generative models: a systematic review

Dimitriadis, Avtantil; Trivizakis, Eleftherios; Papanikolaou, Nikolaos; Tsiknakis, Manolis; Marias, Kostas

doi:10.1186/s13244-022-01315-3

Insights into Imaging

Table 1 Details of the datasets and data processing methods used in the examined studies

From: Enhancing cancer differentiation with synthetic MRI examinations via generative models: a systematic review

Author	Dataset	Patients	Lesion	Modality	Pre-processing	Objective
Beers [38]	BraTS’17	75 LGG 210 HGG	edema non-enhancing/necrosis contrast enhancing	T1w, T1ce T2w, FLAIR	isotropic resample zero mean unit variance	Synthesize
Han [39]	BraTS’16	220 HGG	tumor	T1w, T1ce T2w, FLAIR	skull striping isotropic resample resize	Synthesize
Han [41]	BraTS’16	220 HGG	tumor	T1ce	zero padding	Classification
Han [42]	BraTS’16	220 HGG	tumor	T1ce	zero padding	Classification
Han [44]	Private	180 tumor 193 normal	tumor (brain metastases)	T1ce	skull-striping crop, resize	Detection
Shin [46]	ADNI/ BraTS’15	54 LGG 220 HGG	edema non-enhancing/necrosis contrast enhancing	T1w, T1ce T2w, FLAIR	Skull-striping/ crop axially, resize	Segmentation
Chang [47]	BraTS’18	210	edema non-enhancing/necrosis contrast enhancing	T2w	-	Segmentation
Chang [48]	BraTS’18	210	edema non-enhancing/necrosis contrast enhancing	T1w, T1ce T2w, FLAIR	align isotropic resample resize	Segmentation Slice imputation
Deepak [49]	Figshare database	233	meningioma glioma pituitary tumor	T1ce	Resize	Classification
Qasim [50]	BraTS’19	335	edema non-enhancing/necrosis contrast enhancing	T1w, T2w, FLAIR	-	Segmentation
Kwon [52]	BraTS’18	210	edema non-enhancing/necrosis contrast enhancing	T2w, FLAIR	Resize	Synthesize
Chen [54]	BraTS’13/ IXI	-	edema non-enhancing/necrosis contrast enhancing/ Healthy	- T1w	-	Classification
Pesteie [55]	BraTS’17	-	edema non-enhancing/necrosis contrast enhancing	FLAIR	-	Segmentation
Hamghalam [56]	BraTS’13	30	edema non-enhancing/necrosis contrast enhancing	T1ce	-	Segmentation
Qi [57]	BraTS’19 BraTSs UNS	322 - -	tumor	T1w, T1ce T2w, FLAIR	-	Classification
Guo [58]	Private	90	GBM	T1w, Gd-T1w, T2w FLAIR, APTw	co-registration, skull-stripping N4-bias field correction MRI intensity scale standardization 2D slice extraction	Segmentation
Guo [60]	Private	100	GBM	T1w, Gd-T1w, T2w FLAIR, APTw	co-registration, skull-stripping N4-bias field correction MRI standardization	Segmentation
Ge [66]	TCGA-GBM TCGA-LGG	167	IDH genotype tumor	T1w, T1ce T2w, FLAIR	-	Classification Slice imputation
Ge [67]	TCGA-GBM TCGA-LGG/ BraTS’17	167/ 285	IDH genotype/ edema non-enhancing/necrosis contrast enhancing	T1w, T1ce T2w, FLAIR	-	Classification
Carver [68]	BraTS’18	210	GBM	T1w, T1ce T2w, FLAIR	resample, skull-stripping normalization, padding crop slices	Segmentation
Mok [69]	BraTS’15	220 HGG 54 LGG	edema non-enhancing/necrosis contrast enhancing	T1w, T1ce T2w, FLAIR	skull-stripping co-registration	Segmentation
Dikici [72]	Private	158	tumor (brain metastases)	T1ce	isotropic resample normalization	Detection
Kamli [75]	TCIA ADNI	20	GBM	T1 pre & T1 post contrast T2w, FLAIR	skull-striping normalization/standardisation registration, denoising	Prediction
Li [77]	Private	23 with PSP 61 with TTP	GBM	DTI	-	Classification

LGG, low-grade gliomas; HGG, high-grade gliomas; T1ce, T1 contrast-enhanced; FLAIR fluid-attenuated inversion recovery; T1adjacent w, T1-weighted; T2w, T2-weighted; GBM, glioblastoma multiforme; Gd-T1w, gadolinium-enhanced; APTw, amide proton transfer weighted; IDH, isocitrate dehydrogenase; PSP, pseudoprogression; TTP, true tumor progression; DTI, diffusion tensor imaging, symbol ’-’ represents that the corresponding information was not provided in the publication

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