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Table 1 Clinical characteristics, MRI features of patients in the training and validation group

From: Preoperative prediction of lymph node metastasis in nonfunctioning pancreatic neuroendocrine tumors from clinical and MRI features: a multicenter study

Factors

Training group (n = 66)

Validation group (n = 121)

p

Gender (male/female)

29/37

57/64

0.680

Age, year

53.74 ± 12.11

53.03 ± 14.58

0.740

BMI, kg/m2

24.53 ± 4.04

24.67 ± 3.78

0.820

Symptom (present or absent)

34/32

77 /44

0.011*

NLR

2.36 ± 1.35

3.02 ± 4.02

0.770

TB (< 21/ ≥ 21), μmol/L

53/11

79/12

0.490

ALT (< 40/ ≥ 40), IU/L

55/9

77/14

0.820

AST (< 40/ ≥ 40), IU/L

57/9

82/10

0.600

FBG (< 6.1/ ≥ 6.1), mmol/L

40/23

43/24

0.940

CEA (< 5/ ≥ 5), ng/ml

54/6

84/2

0.070

CA199 (< 37/ ≥ 37), U/ml

52/8

75/11

0.920

CA724 (< 5.9/ ≥ 5.9), U/ml

45/1

46/4

0.360

NSE (< 16.3/ ≥ 16.3), ng/ml

31/15

41/7

0.039*

Lymph node metastasis (N0/N1)

21/45

20/101

0.016*

Tumor location (head or neck/ body/tail)

34/18/14

45/34/42

0.096

SI on T2WI (hypointense/ isointense/hyperintense)

5/45/16

8/81/32

0.930

Maximum diameter of the tumor (< = 20/ > 20 mm)

18/48

47/74

0.040*

Tumor margin (regular/ irregular)

35/31

75/46

0.290

Exophytic growth (present or absent)

36 /30

63/58

0.600

MPDD or CBDD (present or absent)

23/43

35/86

0.403

Hyperenhancement at arterial phase (present or absent)

34/32

64/57

0.860

Homogeneity

42/24

70/51

0.440

Vascular and adjacent tissue involvement (present or absent)

15/51

16/101

0.100

Synchronous liver metastases (present or absent)

18/48

11/110

0.001*

Long axis of the largest lymph node, mm

10.02 ± 7.37

10.39 ± 6.36

0.570

Short axis of the largest lymph node, mm

6.00 ± 4.74

6.19 ± 4.21

0.710

Ratio of the long/short axis of the largest lymph node

1.77 ± 0.53

1.81 ± 0.51

0.610

Abnormal Shape of the largest lymph node (present or absent)

13/53

14/107

0.130

Number of the lymph nodes with the short axis > 5 mm

1.20 ± 1.38

1.22 ± 1.20

0.64

Number of the lymph nodes with the short axis > 10 mm

0.36 ± 0.83

0.24 ± 0.66

0.41

ADCmean(× 10–3 mm2/s)

1470.66 ± 497.53

1554.21 ± 544.41

0.337

ADCmax(× 10–3 mm2/s)

2550.67 ± 1129.81

2110.37 ± 707.05

0.024*

ADCmin(× 10–3 mm2/s)

497.08 ± 646.99

661.49 ± 560.33

0.413

Tumor volume, mm3

66,313.99 ± 259,492.01

53,698.35 ± 277,487.86

0.007*

  1. *p value <0.05 was statistically significant between training and validation group
  2. LNM  lymph node metastasis, BMI  body mass index, TB  total bilirubin, ALT  alanine aminotransferase, AST aspartate aminotransferase, FBG  fasting blood glucose, NLR  neutrophil–lymphocyte ratio, CEA carcinoembryonic antigen, CA199  carbohydrate antigen 199, CA724  carbohydrate antigen 724, NSE  neuron-specific enolase, MPDD main pancreatic duct dilatation, CBDD common bile duct dilatation, ADC apparent diffusion coefficient