Insights into Imaging

Table 1 Demographic and clinical characteristics of the patients in the training and validation cohorts

From: Radiomics analysis of the optic nerve for detecting dysthyroid optic neuropathy, based on water-fat imaging

Characteristics	Training cohort			Validation cohort
	DON	TAO without DON	p value	DON	TAO without DON	p value
Age (years)	50.93 ± 8.39	45.9 ± 8.64	< 0.001	52.57 ± 12.17	47.1 ± 9.0	0.039
Patients (n)	46	42		13	27
Orbits (n)	83	80		21	51
Sex (M/F)	25/21	19/23	0.522	7/6	18/9	0.439
Euthyroid TAO (n)	5	3		2	2
Smoker (n)	18	15	0.818	5	9	0.785
Duration of TAO	5.59 ± 3.77	8.93 ± 10.9	< 0.001	6.29 ± 4.33	6.97 ± 4.9	0.58
VA	0.6 (0.5, 1.0)	0.85 (0.8, 1.0)	< 0.001	0.5(0.25, 0.8)	0.8 (0.8, 1.0)	< 0.001
CAS	4 (2, 5)	2 (1, 2.75)	< 0.001	3 (2, 3)	2 (1.5, 2)	0.002
Proptosis (mm)	19 (18, 21)	19 (17.25, 20)	0.058	19 (18, 20)	19 (18, 20)	0.157
MI (%)	62.66 ± 9.04	58.98 ± 10.68	0.019	70.02 ± 9.54	60.67 ± 9.64	< 0.001
Apical crowding sign (n)	56	19	< 0.001	14	13	0.002
Stretching sign (n)	54	17	< 0.001	13	12	0.003

The continuous data are presented as (mean ± standard deviation) or as median (interquartile range)
The p values are derived from t-tests, Kruskal tests or chi-square tests
CAS, clinical activity score; DON, dysthyroid optic neuropathy; MI, muscle index; Stretching sign, optic nerve stretching sign; TAO, thyroid-associated ophthalmopathy; VA, visual acuity

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