Fig. 1

Hypofractionated adenocarcinoma of the esophagogastric junction (AEG) in a 63-year-old man. A CT venous phase axial image before neoadjuvant chemotherapy (NAC), Borrmann staging type I, thickest tumor diameter of 3.4 cm. B Schematic diagram of region of interest (ROI) segmentation on ITK-SNAP software. C CT venous phase axial image after NAC, lesion near disappearance, and insignificant gastric wall thickening. D Postoperative pathological images; fibrous tissue hyperplasia with chronic inflammatory cell infiltration was seen; no tumor cells remained; and tumor regression was obvious (HE × 200). Hypofractionated AEG in a 36 years old man. E CT venous phase axial image before neoadjuvant chemotherapy (NAC), Borrmann staging type III, thickest tumor diameter of 3.2 cm. F Schematic diagram of region of interest (ROI) segmentation on ITK-SNAP software. G CT venous phase axial image after NAC, significantly smaller lesions with reduced enhancement. H Postoperative pathological images showed more chronic inflammatory cell infiltration in the mucosal and lamina propria layers with focal fibrosis (HE × 200)