Fig. 2
From: Multi-nuclear magnetic resonance spectroscopy: state of the art and future directions
Reproduced with permission from Elsevier Ltd (License Number: 5324100264979). iScience. 2020 Nov 30;23(12):101,885
Metabolism of acute traumatic brain injury (TBI) imaged by hyperpolarized 13C-pyruvate. The patient (35 years old, male), injured on the left frontal scalp, was imaged 28 h after the injury. a An axial slice that includes the injured region was prescribed for 13C imaging. b T1-weighted and T2-weighted 1 H FLAIR and (c) ASL images showed swelling and increased perfusion in the injured site outside the skull (yellow circle), whereas no cerebral contusion, hemorrhage or hypoperfusion were detected. d Region with increased total hyperpolarized 13C signal image matched to the scalp edema. e Increased [1-13C]lactate conversion and (f) decreased [13C]HCO3 – production were detected in the brain tissues of the injured hemisphere. g Averaged spectra over the injured brain region and the contralateral normal-appearing brain region.