Table 3 The ADR occurrence of patients in different patient subgroups

Total number of patients

105/49,676 (0.211)

197/77,524 (0.254)

0.126

Examination sites

 Abdominal

94/30,462 (0.309)

18/15,396 (0.117)

< 0.001

 Non-abdominal

11/19,214 (0.057)

179/62,128 (0.288)

< 0.001

Patient source

 Inpatients

44/21,106 (0.208)

93/40,173 (0.231)

0.566

 Outpatients

61/28,570 (0.214)

104/37,351 (0.278)

0.098

Risk factors and underlying diseases

 ICM-ADR history

12/97 (12.371)

4/165 (2.424)

0.001

 Other ADR histories

11/3536 (0.311)

24/6738 (0.341)

0.709

 Asthma

0/110

2/194 (1.031)

N/A

 Hypertension

16/11,411 (0.140)

57/22,718 (0.251)

0.037

 Coronary heart disease

1/1608 (0.062)

12/4668 (0.257)

0.244

 Heart failure

0/173

2/323 (0.619)

N/A

 Renal insufficiency

1/99 (1.010)

0/151

N/A

 Hyperthyroidism

0/16

0/45

N/A

 Tumor radio-chemotherapy

10/5391 (0.185)

7/5324 (0.131)

0.482

 β blockers

1/1151 (0.087)

41/12,965 (0.316)

0.277

 Diabetes

0/2079

13/3945 (0.330)

N/A

 Age ≥ 70 years

11/9374 (0.117)

20/16,803 (0.119)

0.970

 Injection dose ≥ 100 mL

2/22,859 (0.070)

25/4945 (0.506)

< 0.001

 Injection rate ≥ 5 mL/s

2/12,840 (0.016)

96/28,000 (0.343)

< 0.001

ICM name

 Iopromide 370

22/7833 (0.218)

64/12,532 (0.511)

0.014

 Iodixanol 270

12/3936 (0.305)

25/5490 (0.455)

0.249

 Ioversol 320

7/6693 (0.105)

21/12,244 (0.172)

0.252

 Iohexol 350

15/17,015 (0.088)

27/26,764 (0.101)

0.675

 Iopamidol 350

14/5603 (0.250)

14/9625 (0.145)

0.147

 Iobitridol 350

11/2993 (0.368)

10/4392 (0.228)

0.268

 Iodixanol 320

24/5603 (0.428)

36/6477 (0.556)

0.320