Skip to main content

Table 1 Sensitivity and specificity of predicting disease type or subtype

From: Magnetic resonance imaging in the management of Crohn’s disease: a systematic review and meta-analysis

CD type/subtype

MRE sensitivity (%)

MRE specificity (%)

Logistic regression

Important differentiating MRI feature

Penetrating type

63.7

60.3

p < 0.001

Presence of ulcer on T2-weighted images (T2WIs) [9]

Nonstricturing/non penetrating

58.2

48.4

p < 0.001

Presence of the classical CD features without complications on T2-weighted and gadolinium-enhanced T1-weighted sequences [8]

Stricturing type

63.9

63.2

p < 0.001

Presence of segment(s) of luminal narrowing (fibrotic or inflammatory cause) on unenhanced T2-weighted and gadolinium-enhanced T1-weighted sequences [8]

Inflammatory subtype (Local inflammation, aphthoid and deep ulcers, frequent transmural inflammation with lymphoid aggregates, and granuloma development define the active inflammatory subtype of CD)

73.8

64.9

p < 0.001

Acute inflammation is best seen in T2WIs in fat suppressed sequences; stratified contrast confirms CD is active [9]

Fibro stenotic subtype (persistent intestinal damage, chronic inflammation of the gut wall tends to proceed to fibrostenotic and irreversible consequences (bowel strictures and blockage))

81.5

63.3

p < 0.001

Presence of stenotic segment that persist in the cine images and shows hypointense on T1WIs and T2WIs, and on contrast enhancement shows inhomogenous delayed enhancement [9]

Reparative or regenerative subtype

72.4

64.2

p = 0.005

Luminal narrowing may be seen without any sign of obstruction. Post contrast T1 images showed homogenous continuous enhancement [39]

Fistulizing/perforating subtype (The presence of deep penetrating ulcers, which can lead to the formation of sinus tracts, fistulas, and/or abscesses, characterises it)

61.0

68.9

p = 0.008

Presence of fistula or signs of perforation with adjacent collection, best seen on gadolinium-enhanced T1-weighted sequences [9]