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Table 1 Sensitivity and specificity of predicting disease type or subtype

From: Magnetic resonance imaging in the management of Crohn’s disease: a systematic review and meta-analysis

CD type/subtype MRE sensitivity (%) MRE specificity (%) Logistic regression Important differentiating MRI feature
Penetrating type 63.7 60.3 p < 0.001 Presence of ulcer on T2-weighted images (T2WIs) [9]
Nonstricturing/non penetrating 58.2 48.4 p < 0.001 Presence of the classical CD features without complications on T2-weighted and gadolinium-enhanced T1-weighted sequences [8]
Stricturing type 63.9 63.2 p < 0.001 Presence of segment(s) of luminal narrowing (fibrotic or inflammatory cause) on unenhanced T2-weighted and gadolinium-enhanced T1-weighted sequences [8]
Inflammatory subtype (Local inflammation, aphthoid and deep ulcers, frequent transmural inflammation with lymphoid aggregates, and granuloma development define the active inflammatory subtype of CD) 73.8 64.9 p < 0.001 Acute inflammation is best seen in T2WIs in fat suppressed sequences; stratified contrast confirms CD is active [9]
Fibro stenotic subtype (persistent intestinal damage, chronic inflammation of the gut wall tends to proceed to fibrostenotic and irreversible consequences (bowel strictures and blockage)) 81.5 63.3 p < 0.001 Presence of stenotic segment that persist in the cine images and shows hypointense on T1WIs and T2WIs, and on contrast enhancement shows inhomogenous delayed enhancement [9]
Reparative or regenerative subtype 72.4 64.2 p = 0.005 Luminal narrowing may be seen without any sign of obstruction. Post contrast T1 images showed homogenous continuous enhancement [39]
Fistulizing/perforating subtype (The presence of deep penetrating ulcers, which can lead to the formation of sinus tracts, fistulas, and/or abscesses, characterises it) 61.0 68.9 p = 0.008 Presence of fistula or signs of perforation with adjacent collection, best seen on gadolinium-enhanced T1-weighted sequences [9]