A semiquantitative color Doppler ultrasound scoring system for evaluation of synovitis in joints of patients with blood-induced arthropathy

Zhang, Ningning; Yang, Sheng; Zwagemaker, Anne-Fleur; Huo, Aihua; Li, Ying-Jia; Zhou, Fang; Hilliard, Pamela; Squire, Sandra; Bouskill, Vanessa; Mohanta, Arun; Zhou, Alex; Jarrin, Jose; Wu, Runhui; Sun, Jing; Luke, Brian; Moineddin, Rahim; Blanchette, Victor S.; Peng, Yun; Doria , Andrea S.

doi:10.1186/s13244-021-01043-0

Insights into Imaging

Table 6 Associations between the degree of vascularity on color Doppler and clinical /imaging constructs Hemophilia Joint Health Score (HJHS) of the study joint, Pettersson score of the study joint

From: A semiquantitative color Doppler ultrasound scoring system for evaluation of synovitis in joints of patients with blood-induced arthropathy

US operators (data acquisition)		Correlation coefficient r (95% CIs)	p value	Correlation coefficient r (95% CIs)	p value	Correlation coefficient r (95% CIs)	p value
US operators (data acquisition)		Semi-quantitative color Doppler US scoring method (synovial vascularity)	p value	Quantitative color Doppler US pixel measurement (synovial vascularity)	p value	Quantitative gray-scale US measurement (single-layer synovial hypertrophy)	p value
Canada	Total Pettersson X-rays scores	0.14 (− 0.25, 0.48)	0.49	0.04 (− 0.34, 0.40)	0.85	0.24 (− 0.15, 0.56)	0.22
China	Total Pettersson X-rays scores	0.29 (− 0.06, 0.57)	0.09	0.11 (− 0.25, 0.44)	0.55	0.25 (− 0.10, 0.54)	0.15
Canada	Total HJHS scores	0.21 (− 0.20, 0.55)	0.30	0.31 (− 0.09, 0.62)	0.12	0.53 (0.16–0.75)	0.005
China	Total HJHS scores	0.32 (− 0.10, 0.63)	0.12	− 0.01. (− 0.41, 0.42)	0.97	0.16 (− 0.26–0.52)	0.46
Canada	Presence/absence of swelling (item of HJHS score)	0.32 (− 0.06, 0.61)	0.09	0.38 (0.01, 0.65)	0.04	0.27 (− 0.12–0.57)	0.16
China	Presence/absence of swelling	− 0.16 (− 0.50, 0.23)	0.41	− 0.20 (− 0.54, 0.21)	0.34	− 0.05 (− 0.41–0.33)	0.81
Canada	Duration of swelling (item of HJHS score)	0.10 (− 0.28, 0.45)	0.61	0.23 (− 0.16, 0.54)	0.24	0.06 (− 0.32–0.41)	0.77
China	Duration of swelling	− 0.01 (− 0.39, 0.36)	0.94	0.12 (− 0.28, 0.48)	0.56	− 0.06 (− 0.42–0.32)	0.77
Canada	Flexion loss (item of HJHS score)	0.24 (− 0.15, 0.55)	0.22	0.16 (− 0.22, 0.50)	0.41	0.07 (− 0.31–0.42)	0.72
China	Flexion loss	0.38 (− 0.00, 0.65)	0.048	0.40 (0.00, 0.68)	0.04	0.27 (− 0.12–0.58)	0.17
Canada	Extension loss (item of HJHS score)	0.34 (− 0.04, 0.62)	0.07	0.25 (− 0.13, 0.56)	0.18	0.39 (0.01–0.65)	0.04
China	Extension loss	0.09 (− 0.30, 0.45)	0.65	− 0.16 (− 0.51, 0.24)	0.43	0.10 (− 0.29–0.45)	0.61
Canada	Pain (item of HJHS score)	0.23 (− 0.16, 0.54)	0.24	0.13 (− 0.25, 0.47)	0.52	0.34 (− 0.04–0.62)	0.07
China	Pain	0.21 (− 0.18, 0.54)	0.28	0.09 (− 0.31, 0.46)	0.68	0.29 (− 0.10–059)	0.14

Bold indicates statistically significant results. p values < 0.05 were considered statistically significant
CI, confidence intervals; R, correlation coefficient

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