Fig. 4
From: Giant cell tumour of the tendon sheath of the spine: clinical features and imaging findings
A Benign GCTTS showed mixed inflammatory cells, foam cells and haemosiderin, accompanied by multinucleated giant cells (white arrow) and fibrosis. The cells had no obvious atypia, HE 10 × 10. B Malignant GCTTS showed multifocal cystic changes, necrosis and haemorrhage (black arrow), HE 10 × 10. C Malignant GCTTS comprised densely arranged splindle mononuclear cells, showing enlarged nuclei and an increased mitotic count. Multinucleated giant cells could be identified among the mononuclear components, HE 10 × 40