Table 2 Causal factors of equivocal lesions during the oncologic assessment
From: RECIST 1.1 and lesion selection: How to deal with ambiguity at baseline?
Related type of cause | Risk factors for ambiguous lesion |
|---|---|
Technical | Poor quality of the examination Artefact: kinetic or any other |
Protocol | Absence of imaging without contrast-agent Absence of triphasic acquisition for liver analysis |
Contrast | Contraindication of contrast-agent |
Lesion | Small size (non-specific very small lesions) Low conspicuity (small size, ground glass…) Radiological semiology in the malignancy/benign overlap zone |
Study design (blinded, centralized review) | Lack or imprecise data on previous local therapy or biopsy |