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Table 1 Factors of inter-reader variability for selecting lesion at baseline following RECIST 1.1 guidance

From: RECIST 1.1 and lesion selection: How to deal with ambiguity at baseline?

Category of targets

TL

NTL

Factors of inter-reader variability

Size measurement variability for small centimetric lesions (10 mm measurability threshold)

Confidence of measuring (e.g., Ill-defined lesions, artefacts)

Reproducibility of measurement is not ensured (e.g., position of the lesion, digestive tract lesion)

Equivocal malignancy (i.e., benign lesion mimicking malignant lesion, small undetermined lesions)

Several grouped lesions recorded as one NTL

Undefined number of NTL

Equivocal malignancy (i.e., benign lesion mimicking malignant lesion, small undetermined lesions)