Fig. 12

Illustration of the two main types of tumor necrosis. Gross pathology (a) and histological view (b) of a large and rapidly growing resected liver metastasis with acinar necrosis in a 58-year-old male patient with non-otherwise specified (NOS) colon cancer. The central acinar necrosis (black star) is characterized by tumoral glands (T) containing nuclear debris (nd). Note the fibrotic stroma (F) surrounding the tumoral cells (T). Gross pathology (c) and histological view (d) of a liver metastasis containing infarct-like necrosis in a 54-year-old female patient with NOS colon cancer treated with chemotherapy. A large necrotic tumor with fibrotic changes (F) was observed at gross pathology. Histology showed a large confluent area of ischemic necrosis (N)